{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:47:14Z","timestamp":1777927634795,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1990,9,1]],"date-time":"1990-09-01T00:00:00Z","timestamp":652147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:p>\n                    The purpose of the study was to characterize in vivo an immunodepressive murine retroviral \u2018model\u2019 for the possible testing of drugs against HIV infection. Urethane leukaemia virus (ULV) injected into adult BALB\/c mice (10\n                    <jats:sup>5<\/jats:sup>\n                    focus-forming units\/mouse) caused a small, significant splenomegaly from 2 to at least 9 weeks after virus inoculation. Virus was also present in up to 60% nucleated splenocytes (XC \u2018infectious centre assay\u2019).\n                  <\/jats:p>\n                  <jats:p>Effects on splenomegaly and virus in splenocytes were assayed following various regimens of zidovudine given as 0.5 mg\/ml or 0.25 mg\/ml in drinking water. Regimens included continuous treatment both before and after ULV only before, and only after ULV inoculation. Zidovudine was also given for limited period immediately after virus or initiated after virus infection was established.<\/jats:p>\n                  <jats:p>Zidovudine given continuously at and following ULV infection completely prevented splenomegaly and virus expression in splenocytes. No other regimen was as effective; however, limited zidovudine treatment immediately after virus moculation greatly reduced the effects of virus, while the same dose initiated after virus infection was established had only a small ameliorating effect.<\/jats:p>\n                  <jats:p>We conclude that ULV may prove to be a useful addition to other available murine systems, and this is discussed.<\/jats:p>","DOI":"10.1177\/095646249000100510","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T19:38:39Z","timestamp":1484595519000},"page":"349-356","source":"Crossref","is-referenced-by-count":2,"title":["Inhibition of Urethane Leukaemia Virus, a Murine Retrovirus, in Mice by Zidovudine"],"prefix":"10.1177","volume":"1","author":[{"given":"T T","family":"Harvey","sequence":"first","affiliation":[{"name":"Division of Sexually Transmitted Diseases, MRC Clinical Research Centre, Harrow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Tuffrey","sequence":"additional","affiliation":[{"name":"Division of Sexually Transmitted Diseases, MRC Clinical Research Centre, Harrow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Wedderburn","sequence":"additional","affiliation":[{"name":"Department of Pathology, Royal College of Surgeons, Lincoln's Inn Fields, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Sexually Transmitted Diseases, MRC Clinical Research Centre, Harrow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Pathology, Royal College of Surgeons, Lincoln's Inn Fields, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Taylor-Robinson","sequence":"additional","affiliation":[{"name":"Division of Sexually Transmitted Diseases, MRC Clinical Research Centre, Harrow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Dor\u00e9","sequence":"additional","affiliation":[{"name":"Division of Sexually Transmitted Diseases, MRC Clinical Research Centre, Harrow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,9,1]]},"reference":[{"key":"bibr1-095646249000100510","doi-asserted-by":"crossref","unstructured":"Editorial. 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Antigen Assay. \u201cCoulter TM HIV Ag Assay\u201d. Handbook."},{"key":"bibr26-095646249000100510","doi-asserted-by":"publisher","DOI":"10.1038\/323467a0"},{"key":"bibr27-095646249000100510","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(75)90013-6"},{"key":"bibr28-095646249000100510","unstructured":"Jerne NK, Nordin AA, Henry C. The agar plaque technique for recognizing antibody-producing cells. In: Amos B, Koprowski H, eds. Cell bound antibodies. 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