{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:06:00Z","timestamp":1789909560356,"version":"4.0.1"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1993,7,1]],"date-time":"1993-07-01T00:00:00Z","timestamp":741484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:p>The efficacy and safety of topical treatment for external condylomata acuminata with either self-applied 0.5% podophyllotoxin (PT) or hospital-applied 25% podophyllin (PODO) solution was compared in 138 males and 67 females in an open multicentre study. After one week of treatment, wart clearance was observed in 53% of males and 37% of females in the PT group as compared with 19% of males and 19% of females in the PODO group ( P &lt; 0.001 in males; P = 0.13 in females). At 5 weeks after commencing treatment, clearance of warts had been achieved in 86% males and 72% females in the PT group as compared with 78% of males and 62% females in the PODO group ( P = 0.08 in males; P = 0.14 in females). Treatment had cleared 81% of 180 treated sites in all PT recipients as compared with 61% of 95 treated sites in all PODO recipients ( P &lt; 0.001). The increased speed of action of PT was associated with an increased incidence of symptoms and signs of inflammation at treatment sites in both males and females ( P &lt; 0.001). These were generally mild, did not interfere with continuing treatment, and were more frequent in those patients whose warts were eradicated most rapidly.<\/jats:p>\n                  <jats:p>Home-based treatment with 0.5% podophyllotoxin lotion in appropriately instructed patients of either sex is superior in efficacy to outpatient applied 25% podophyllin and has the potential to reduce the number of hospital attendances required in genital wart eradication.<\/jats:p>","DOI":"10.1177\/095646249300400403","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T10:59:19Z","timestamp":1484477959000},"page":"194-199","source":"Crossref","is-referenced-by-count":27,"title":["An Open, Comparative, Study of the Efficacy of 0.5% Podophyllotoxin Lotion and 25% Podophyllotoxin Solution in the Treatment of Condylomata Acuminata in Males and Females"],"prefix":"10.1177","volume":"4","author":[{"given":"G R","family":"Kinghorn","sequence":"first","affiliation":[{"name":"Department of Genitourinary Medicine, Royal Hallamshire Hospital, Sheffield"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"McMillan","sequence":"additional","affiliation":[{"name":"Royal Infirmary, Edinburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Mulcahy","sequence":"additional","affiliation":[{"name":"St James' Hospital, Dublin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Drake","sequence":"additional","affiliation":[{"name":"Heartlands Hospital, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lacey","sequence":"additional","affiliation":[{"name":"General Infirmary, Leeds"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Bingham","sequence":"additional","affiliation":[{"name":"St Thomas' Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1993,7,1]]},"reference":[{"key":"bibr1-095646249300400403","first-page":"263","volume":"64","author":"Edwards A.","year":"1988","journal-title":"Genitourin Med"},{"key":"bibr2-095646249300400403","first-page":"31","volume":"1","author":"Lassus A","year":"1984","journal-title":"Eur J Sex Trans Dis"},{"key":"bibr3-095646249300400403","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91823-X"},{"key":"bibr4-095646249300400403","first-page":"1387","volume":"61","author":"Mazurkiewicz W","year":"1985","journal-title":"Z Hautkrank"},{"key":"bibr5-095646249300400403","first-page":"1223","volume":"11","author":"Landthaler M","year":"1987","journal-title":"Dt Dermatol"},{"key":"bibr6-095646249300400403","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92282-4"},{"key":"bibr7-095646249300400403","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90424-C"},{"key":"bibr8-095646249300400403","first-page":"186","volume":"78","author":"Huwyler T.","year":"1989","journal-title":"Schweiz Rundschau Med"},{"key":"bibr9-095646249300400403","first-page":"65","volume":"125","author":"Caresana G","year":"1990","journal-title":"Giornale Italiano di Dermatohgia e Venereologia"},{"key":"bibr10-095646249300400403","first-page":"656","volume":"76","author":"Baker DA","year":"1990","journal-title":"Obstet Gynecol"},{"key":"bibr11-095646249300400403","doi-asserted-by":"publisher","DOI":"10.3109\/09546639009086712"},{"key":"bibr12-095646249300400403","first-page":"735","volume":"77","author":"Greenberg MD","year":"1991","journal-title":"Obstet Gynecol"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/095646249300400403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/095646249300400403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:50:40Z","timestamp":1777675840000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/095646249300400403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1177\/095646249300400403"],"URL":"https:\/\/doi.org\/10.1177\/095646249300400403","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}