{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:48:05Z","timestamp":1777927685817,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1993,9,1]],"date-time":"1993-09-01T00:00:00Z","timestamp":746841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:p>This was an open, single centre study, to evaluate the safety and efficacy of ondansetron in the treatment of co-trimoxazole associated nausea and vomiting in AIDS patients. Sixteen patients presenting with their first episode of HIV-associated Pneumocystis carinii pneumonia (PCP) on high dose co-trimoxazole were given ondansetron 8 mg orally, every 8h. Measurements were made from data recorded by each patient on diary cards.<\/jats:p>\n                  <jats:p>In this study 11 out of 16 (69%) patients on ondansetron experienced good control of emesis (2 or less emetic episodes) on their \u2018worst day\u2019 of therapy and 8 out of 16 (50%) of patients demonstrated good control of emesis throughout their treatment with co-trimoxazole. Good control of nausea (mild or none) was achieved in 7 out of 16 (47%) patients. A total of 7 patients were able to complete the full course of co-trimoxazole whilst on ondansetron. One serious adverse event (Stevens-Johnson syndrome) was reported and felt to be unrelated to ondansetron.<\/jats:p>\n                  <jats:p>If conventional anti-emetics fail to achieve control of symptoms or have unacceptable side effects, ondansetron may represent a possible alternative.<\/jats:p>","DOI":"10.1177\/095646249300400508","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T03:11:11Z","timestamp":1484536271000},"page":"293-296","source":"Crossref","is-referenced-by-count":5,"title":["Ondansetron Usage in HIV Positive Patients: A Pilot Study on the Control of Nausea and Vomiting in Patients on High Dose Co-Trimoxazole for\n                    <i>Pneumocystis Carinii<\/i>\n                    Pneumonia"],"prefix":"10.1177","volume":"4","author":[{"given":"M","family":"Gompels","sequence":"first","affiliation":[{"name":"Department of Immunology, St Mary's Hospital, London W2 1PG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"McWilliams","sequence":"additional","affiliation":[{"name":"Department of Immunology, St Mary's Hospital, London W2 1PG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"O'Hare","sequence":"additional","affiliation":[{"name":"Department of Glaxo Group Research, Greenford, Middlesex London UB6 0HE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R W","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Genito Urinary Medicine, St Mary's Hospital, London W2 1PG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Pinching","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Main","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Mary's Hospital, London W2 1PG"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,9,1]]},"reference":[{"key":"bibr1-095646249300400508","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/68.5.466"},{"key":"bibr2-095646249300400508","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199009203231202"},{"key":"bibr3-095646249300400508","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-1-45"},{"key":"bibr4-095646249300400508","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-1-37"},{"key":"bibr5-095646249300400508","unstructured":"Breitbart W, Marotta R, Platt M, Corbera K, Weisman H, Dorfman D. Extrapyramidal symptoms in medically hospitalized AIDS patients receiving neuroleptics. Abstracts from\n                      VIth International AIDS conference\n                      1990;A:349.(abstract)."},{"key":"bibr6-095646249300400508","first-page":"s5","volume":"27","author":"Gralla RJ","year":"1991","journal-title":"Eur J Cancer"},{"key":"bibr7-095646249300400508","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-5-663"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/095646249300400508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/095646249300400508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:50:48Z","timestamp":1777675848000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/095646249300400508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1177\/095646249300400508"],"URL":"https:\/\/doi.org\/10.1177\/095646249300400508","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}