{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:46:11Z","timestamp":1779914771419,"version":"3.53.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1994,5,1]],"date-time":"1994-05-01T00:00:00Z","timestamp":767750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:p>A randomized, double-blind, placebo-controlled trial was conducted to assess interferon-beta efficacy and safety in the treatment of anogenital condylomatous lesions.<\/jats:p>\n                  <jats:p>One hundred patients received a daily intramuscular injection of either interferon-beta (IFN-\u03b2) (2 MIU\/day) or placebo for 10 days.<\/jats:p>\n                  <jats:p>Of 94 evaluable patients, the complete response rate observed 8 weeks after treatment was significantly higher in the group receiving IFN-\u03b2, as compared to the placebo-treated group (51% vs 28.9%, P&lt;0.05).<\/jats:p>\n                  <jats:p>After one year, 24 patients (100%) out of 24 complete responders to IFN-\u03b2 who attended for follow-up remained free of lesions. Twelve of 13 patients with complete response to placebo (92.3%) remained free of lesions after one year.<\/jats:p>\n                  <jats:p>Side effects were mild and no significant analytical changes were observed.<\/jats:p>\n                  <jats:p>In conclusion, interferon-beta is an effective and safe treatment for long-term eradication of anogenital condylomatous lesions.<\/jats:p>","DOI":"10.1177\/095646249400500305","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T12:20:13Z","timestamp":1484655613000},"page":"182-185","source":"Crossref","is-referenced-by-count":11,"title":["Double-Blind, Randomized Clinical Trial on the Effect of Interferon-Beta in the Treatment of Condylomata Acuminata"],"prefix":"10.1177","volume":"5","author":[{"given":"L","family":"Olmos","sequence":"first","affiliation":[{"name":"Dermatology and STD Departments of: Hospital Cl\u00ednico Universitario \u2018San Carlos\u2019, Madrid, Hospital Cl\u00ednico, Sevilla, Hospital General Universitario, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Vilata","sequence":"additional","affiliation":[{"name":"Dermatology and STD Departments of: Hospital Cl\u00ednico Universitario \u2018San Carlos\u2019, Madrid, Hospital Cl\u00ednico, Sevilla, Hospital General Universitario, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Rodr\u00edguez","family":"Pichardo","sequence":"additional","affiliation":[{"name":"Dermatology and STD Departments of: Hospital Cl\u00ednico Universitario \u2018San Carlos\u2019, Madrid, Hospital Cl\u00ednico, Sevilla, Hospital General Universitario, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lloret","sequence":"additional","affiliation":[{"name":"Dermatology and STD Departments of: Hospital Cl\u00ednico Universitario \u2018San Carlos\u2019, Madrid, Hospital Cl\u00ednico, Sevilla, Hospital General Universitario, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Dermatology and STD Departments of: Hospital Cl\u00ednico Universitario \u2018San Carlos\u2019, Madrid, Hospital Cl\u00ednico, Sevilla, Hospital General Universitario, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M D","family":"Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Dermatology and STD Departments of: Hospital Cl\u00ednico Universitario \u2018San Carlos\u2019, Madrid, Hospital Cl\u00ednico, Sevilla, Hospital General Universitario, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1994,5,1]]},"reference":[{"key":"bibr1-095646249400500305","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290205"},{"key":"bibr2-095646249400500305","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)31056-8"},{"key":"bibr3-095646249400500305","first-page":"31","author":"Richart RM","year":"1984","journal-title":"Diagnost Med"},{"key":"bibr4-095646249400500305","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/4.Supplement_4.S829"},{"key":"bibr5-095646249400500305","first-page":"393","volume":"74","author":"Panici P Benedetti","year":"1989","journal-title":"Obstet Gynecol"},{"key":"bibr6-095646249400500305","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90676-8"},{"key":"bibr7-095646249400500305","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37326-3"},{"key":"bibr8-095646249400500305","first-page":"23","volume":"1","author":"Stefanon D.","year":"1983","journal-title":"The Cervix & LFGT"},{"key":"bibr9-095646249400500305","first-page":"104","volume":"19","author":"Marcovici R","year":"1983","journal-title":"Isr J Med Sci"},{"key":"bibr10-095646249400500305","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-5-675"},{"key":"bibr11-095646249400500305","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91450-8"},{"key":"bibr12-095646249400500305","first-page":"203","volume":"8","author":"Costa S","year":"1988","journal-title":"The Cervix & LFGT"},{"issue":"1","key":"bibr13-095646249400500305","first-page":"30","author":"Piccoli R","year":"1989","journal-title":"Clin Exp Obstet Gynecol"},{"issue":"12","key":"bibr14-095646249400500305","first-page":"595","volume":"42","author":"Fallani MG","year":"1991","journal-title":"Minerva Ginecol"},{"key":"bibr15-095646249400500305","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131304"},{"key":"bibr16-095646249400500305","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7914"},{"issue":"2","key":"bibr17-095646249400500305","first-page":"120","volume":"19","author":"Resta L","year":"1992","journal-title":"Clin Exp Obstet Gynecol"}],"container-title":["International Journal of STD &amp; 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