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The present study related law-school expectancies to cell-mediated immunity (CMI), examining the within- and between-person components of this relationship and affective mediators. First-year law students ( N = 124) completed questionnaire measures of expectancies and affect and received delayed-type hypersensitivity skin tests at five time points. A positive relationship between optimistic expectancies and CMI occurred: Changes in optimism correlated with changes in CMI. Likewise, changes in optimism predicted changes in positive and, to a lesser degree, negative affect, but the relationship between optimism and immunity was partially accounted for only by positive affect. This dynamic relationship between expectancies and immunity has positive implications for psychological interventions to improve health, particularly those that increase positive affect.<\/jats:p>","DOI":"10.1177\/0956797610362061","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:09:54Z","timestamp":1267056594000},"page":"448-455","source":"Crossref","is-referenced-by-count":113,"title":["Optimistic Expectancies and Cell-Mediated Immunity"],"prefix":"10.1177","volume":"21","author":[{"given":"Suzanne C.","family":"Segerstrom","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.","family":"Sephton","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences, University of Louisville"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"bibr1-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.84.5.888"},{"key":"bibr2-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.092"},{"key":"bibr3-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.03.005"},{"key":"bibr4-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.51.6.1173"},{"key":"bibr5-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199811000-00009"},{"key":"bibr6-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199522240-00011"},{"key":"bibr7-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.1998.0531"},{"key":"bibr8-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01888-7"},{"key":"bibr9-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.80.5.804"},{"key":"bibr10-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1111\/1469-8986.00067"},{"key":"bibr11-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.1.79"},{"key":"bibr12-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.12.2.121"},{"key":"bibr13-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1111\/1467-8721.00003"},{"key":"bibr14-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1207\/s15327558ijbm1202_6"},{"key":"bibr15-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.14.1.74"},{"key":"bibr16-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198407000-00010"},{"key":"bibr17-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.131.6.803"},{"key":"bibr18-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1080\/08870440310001652696"},{"key":"bibr19-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.55.1.44"},{"key":"bibr20-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.131.6.925"},{"key":"bibr21-0956797610362061","volume-title":"Stress, immune function, and health: The connection","author":"Rabin B.S.","year":"1999"},{"key":"bibr22-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.18.4.354"},{"key":"bibr23-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.13.4.299"},{"key":"bibr24-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.67.6.1063"},{"key":"bibr25-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20076"},{"key":"bibr26-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.11.2.304"},{"key":"bibr27-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012271410485"},{"key":"bibr28-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2004.08.003"},{"key":"bibr29-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.25.5.653"},{"key":"bibr30-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.74.6.1646"},{"key":"bibr31-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1016\/0889-1591(92)90014-F"},{"key":"bibr32-0956797610362061","first-page":"135","volume-title":"Modeling intraindividual variability with repeated measures data: Methods and applications","author":"Singer J.D.","year":"2002"},{"key":"bibr33-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1111\/j.1559-1816.2009.00508.x"},{"key":"bibr34-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.52.5.988"},{"key":"bibr35-0956797610362061","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.54.6.1020"},{"key":"bibr36-0956797610362061","doi-asserted-by":"crossref","unstructured":"Watson D., Clark L.A. 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