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We hypothesized that the orbitofrontal cortex (OFC) is a central substrate for olfactory conscious experience because of its privileged physiological role in odor processing. Combining functional magnetic resonance imaging, peripheral autonomic recordings, and olfactory psychophysics, we studied a case of complete anosmia (smell loss) in a patient with circumscribed traumatic brain injury to the right OFC. Despite a complete absence of conscious olfaction, the patient exhibited robust \u201cblind smell,\u201d as indexed by reliable odor-evoked neural activity in the left OFC and normal autonomic responses to odor hedonics during presentation of stimuli to the left nostril. These data highlight the right OFC\u2019s critical role in subserving human olfactory consciousness.<\/jats:p>","DOI":"10.1177\/0956797610382121","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T01:11:20Z","timestamp":1287364280000},"page":"1454-1463","source":"Crossref","is-referenced-by-count":98,"title":["Right Orbitofrontal Cortex Mediates Conscious Olfactory Perception"],"prefix":"10.1177","volume":"21","author":[{"given":"Wen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Wisconsin\u2013Madison"},{"name":"The Waisman Institute, University of Wisconsin\u2013Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Lopez","sequence":"additional","affiliation":[{"name":"Cognitive Neurology & Alzheimer\u2019s Disease Center, Northwestern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Osher","sequence":"additional","affiliation":[{"name":"Cognitive Neurology & Alzheimer\u2019s Disease Center, Northwestern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd B.","family":"Parrish","sequence":"additional","affiliation":[{"name":"Cognitive Neurology & Alzheimer\u2019s Disease Center, Northwestern University"},{"name":"Department of Radiology, Northwestern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay A.","family":"Gottfried","sequence":"additional","affiliation":[{"name":"Cognitive Neurology & Alzheimer\u2019s Disease Center, Northwestern University"},{"name":"Department of Neurology, Northwestern University"},{"name":"Department of Psychology, Northwestern University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,9,3]]},"reference":[{"key":"bibr1-0956797610382121","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(83)90045-3"},{"key":"bibr2-0956797610382121","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1940.128.4.754"},{"key":"bibr3-0956797610382121","doi-asserted-by":"publisher","DOI":"10.1038\/nn1001"},{"key":"bibr4-0956797610382121","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903460306"},{"key":"bibr5-0956797610382121","doi-asserted-by":"publisher","DOI":"10.1038\/nn0203-119"},{"key":"bibr6-0956797610382121","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2006.03.007"},{"key":"bibr7-0956797610382121","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198402000-00004"},{"key":"bibr8-0956797610382121","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2906"},{"key":"bibr9-0956797610382121","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2006.08.004"},{"key":"bibr10-0956797610382121","unstructured":"Functional Imaging Laboratory. 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