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Interventions supporting protective and responsive caregiving offer a promising approach to attenuating adversity-induced changes in stress-sensitive biomarkers. This study tested whether participation in an evidence-based dyadic psychosocial intervention, child\u2013parent psychotherapy (CPP), was related to lower epigenetic age acceleration, a trauma-sensitive biomarker of accelerated biological aging that is associated with later health impairment, in a sample of children with trauma histories. Within this quasi-experimental, repeated-measures study, we examined epigenetic age acceleration at baseline and postintervention in a low-income sample of children receiving CPP treatment (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 45; age range = 2\u20136 years; 76% Latino) compared with a weighted, propensity-matched community-comparison sample (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 110; age range = 3\u20136 years; 40% Latino). Baseline epigenetic age acceleration was equivalent across groups. However, posttreatment, epigenetic age acceleration in the treatment group was lower than in the matched community sample. Findings highlight the potential for a dyadic psychosocial intervention to ameliorate accelerated biological aging in trauma-exposed children.\n                  <\/jats:p>","DOI":"10.1177\/09567976241260247","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T11:00:16Z","timestamp":1723633216000},"page":"1062-1073","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Intervening After Trauma: Child\u2013Parent Psychotherapy Treatment Is Associated With Lower Pediatric Epigenetic Age Acceleration"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-9578","authenticated-orcid":false,"given":"Alexandra D. 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