{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:59:28Z","timestamp":1792803568626,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Swedish governmental clinical research, regional research support for clinical trials"},{"name":"Nils Gunnar Henrikssons fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vestibular Research"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The efficacy of corticosteroids for treating acute vestibular neuritis, or acute unilateral vestibulopathy (AUVP), remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate whether corticosteroids improve vestibular function and reduce symptoms in both acute and chronic phases of AUVP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized, placebo-controlled, double-blind trial included patients with AUVP (ages 18\u201380) from emergency departments at three sites in southern Sweden. Patients were randomly assigned to one of three groups: placebo, 3-day or 10-day corticosteroid treatment. The steroid groups received intravenous betamethasone followed by oral steroids, while the placebo group received intravenous saline followed by oral placebo. The primary outcome was canal paresis (%) after 12\u00a0months, measured via caloric testing. Secondary outcomes included vHIT gain, Diary Vertigo score, Dizziness Handicap Inventory, and Hospital Anxiety and Depression Scale. Analyses were conducted on an intention-to-treat basis. The trial was registered with the EU Clinical Trials Register (EudraCT Number: 2014-005484-32) and ClinicalTrials.gov (NCT00802529).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From December 2015 to March 2021, 350 patients were screened, and 69 were included: 23 in the 10-day corticosteroid group, 22 in the 3-day corticosteroid group, and 24 in the placebo group. All groups showed significant improvement in caloric function over time (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .002), with no significant differences between groups at any time point (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .629). Change in caloric asymmetry from baseline to 12\u00a0months did not differ between the treatment groups and the placebo group: mean difference \u22128.34 (95% CI \u201325.93 to 9.26;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .347) in the 10-day steroid group and \u22126.61 (\u221224.67 to 11.45;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .467) in the 3-day steroid group, compared with placebo. Secondary outcomes showed no significant differences between groups. Corticosteroid treatments were well tolerated with no safety concerns.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Corticosteroid treatment does not significantly improve caloric recovery, vHIT gain recovery, or subjective well-being in patients with AUVP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09574271241307649","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:02:07Z","timestamp":1739836927000},"page":"91-101","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute unilateral vestibulopathy and corticosteroid treatment - A randomized placebo-controlled double-blind trial"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4060-8988","authenticated-orcid":false,"given":"Julia","family":"Sj\u00f6gren","sequence":"first","affiliation":[{"name":"Lund University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Anders","family":"Fransson","sequence":"additional","affiliation":[{"name":"Lund University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4266-1996","authenticated-orcid":false,"given":"M\u00e5ns","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Lund University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Karlberg","sequence":"additional","affiliation":[{"name":"Lund University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1446-8224","authenticated-orcid":false,"given":"Fredrik","family":"Tjernstr\u00f6m","sequence":"additional","affiliation":[{"name":"Lund University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/VES-220201"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/VES-2009-0357"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200002000-00006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2010-0533"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.48"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/VES-180645"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182267e24"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033280"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4556-1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002106"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182009f35"},{"key":"e_1_3_3_13_2","first-page":"CD008607","article-title":"Corticosteroids for the treatment of idiopathic acute vestibular dysfunction (vestibular neuritis)","volume":"5","author":"Fishman JM","year":"2011","unstructured":"Fishman JM, Burgess C, Waddell A. 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