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Her attacks subsided within 48\u00a0h after the start of magnesium substitution and the patient remained confused and ataxic with a gradual but full recovery over 6\u00a0weeks. Hypomagnesemia resulted most probably from long-term proton\u2014pump inhibitor (PPI) intake. Paroxysmal downbeat nystagmus is rare and has so far only been consistently described in association with hypomagnesemia of various causes.<\/jats:p>","DOI":"10.1177\/09574271251351939","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T08:00:37Z","timestamp":1751270437000},"page":"328-335","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Paroxysmal downbeat nystagmus, a case report and a review of the literature"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1909-8973","authenticated-orcid":false,"given":"Mehdi","family":"Rhaddioui","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Luxembourg, Centre Hospitalier Emile Mayrisch, Esch-sur-Alzette, Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6510-4298","authenticated-orcid":false,"given":"Alexandre","family":"Bisdorff","sequence":"additional","affiliation":[{"name":"Clinique du Vertige, Centre Hospitalier Emile Mayrisch, Esch-sur-Alzette, Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1326879"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006385"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.01.013"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebcr.2015.07.003"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040030579023"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.11.1239"},{"issue":"2","key":"e_1_3_4_8_2","first-page":"80","article-title":"Chiari I malformation presenting as downbeat nystagmus: clinical presentation, diagnosis, and management","volume":"83","author":"Goodwin D","year":"2012","unstructured":"Goodwin D, Halvorson AR. 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