{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:32Z","timestamp":1792787672508,"version":"4.5.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Research Foundation","award":["NRF-2022R1F1A1074440"],"award-info":[{"award-number":["NRF-2022R1F1A1074440"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vestibular Research"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study aimed to identify blood-based inflammatory biomarkers that would help investigate the underlying pathogenesis in vestibular neuritis (VN) using a proximity extension assay (PEA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-center prospective study, we enrolled both a cross-sectional (acute VN vs normal controls) and a longitudinal (acute phase vs recovery phase) cohorts. We quantified 92 plasma inflammatory proteins using the Olink PEA and identified differentially expressed proteins (DEPs) in each cohort using t-tests. The clinical utility and predictive value of each DEP were evaluated using the Pearson correlation test and receiver operating characteristic (ROC) curve analysis, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the cross-sectional cohort, there were 17 DEPs identified between acute VN (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 35) and normal controls (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 35), of which Flt3L was the only downregulated DEP that showed longitudinal changes congruent with clinical disease activity in the longitudinal cohort (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 18). The correlation analysis revealed that the expression level of CXCL5 was significantly related to the absolute gain and gain asymmetry of the horizontal vestibulo-ocular reflex, while five DEPs (OSM, Flt3L, IFN-\u03b3, MCP-1, and uPA) were negatively correlated with the hospitalization period. ROC curves showed that CXCL1 and Flt3L were upregulated and downregulated DEPs with high predictive values, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study shows that the high-throughput PEA technology can be used to identify blood-based inflammatory biomarkers for VN. Our findings highlight the potential value of Flt3L and CXCL1\/CXCL5 as objective VN markers that may correlate with disease activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09574271261418550","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:50:26Z","timestamp":1768809026000},"page":"452-461","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of blood-based inflammatory biomarkers for vestibular neuritis using a proximity extension assay"],"prefix":"10.1177","volume":"36","author":[{"given":"Eun Hye","family":"Oh","sequence":"first","affiliation":[{"name":"Pusan National University Yangsan Hospital"},{"name":"Seo Il Medical Group Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Pusan National University Yangsan Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ok","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Pusan National University School of Medicine and Biomedical Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Dong","family":"Choi","sequence":"additional","affiliation":[{"name":"Pusan National University School of Medicine and Biomedical Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4120-9228","authenticated-orcid":false,"given":"Jae-Hwan","family":"Choi","sequence":"additional","affiliation":[{"name":"Pusan National University Yangsan Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2015.04.012"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1354598"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53488-0.00037-7"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/v16010012"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509121878"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.6.880"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21904"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199909)46:3<416::AID-ANA20>3.0.CO;2-W"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00331-17"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00591"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.570638"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/VES-220201"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpph.19"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480260094956"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-N2074"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000320839"},{"issue":"5","key":"e_1_3_4_18_2","first-page":"S447","article-title":"T-lymphocyte subpopulations and HLA-DR antigens in patients with Bell's palsy, hearing loss, neuronitis vestibularis, and M\u00e9ni\u00e8re's disease","volume":"70","author":"Bumm P","year":"1994","unstructured":"Bumm P, Schlimok G. 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