{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:17:04Z","timestamp":1787926624603,"version":"build-2784847793"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2025-02223226"],"award-info":[{"award-number":["RS-2025-02223226"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2025-00553480"],"award-info":[{"award-number":["RS-2025-00553480"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vestibular Research"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To test whether interictal plasma or salivary calcitonin gene-related peptide (CGRP) distinguishes M\u00e9ni\u00e8re disease (MD) from vestibular migraine (VM), chronic migraine (CM), and healthy controls (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adults with MD (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 53), VM (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 81), CM (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 73), and HC (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 59) provided morning interictal plasma and saliva. CGRP was measured in duplicate by ELISA. The primary contrast was plasma CGRP in MD versus VM; secondary analyses included multiplicity-corrected pairwise contrasts and ROC analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma CGRP differed among groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). Plasma CGRP in MD was higher than VM (75.2 [54.8\u201386.5] vs 37.1 [22.4\u201360.4] pg\/mL; adjusted\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and HC (37.7 [27.7\u201357.4] pg\/mL; adjusted\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), but similar to CM (74.6 [49.6\u2013101.6] pg\/mL). Salivary CGRP differed overall (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.001), driven mainly by CM versus HC, and did not separate MD from VM or HC. Plasma CGRP did not differ by headache status within MD. Plasma CGRP yielded an MD-versus-VM AUC of 0.805.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Interictal plasma CGRP is elevated in MD relative to VM and HC, appearing independent of headache status. This assay-specific signal may support MD-versus-VM differentiation as a biological adjunct, but overlap with CM, absent severity correlations, and lack of external validation preclude disease-specific or stand-alone interpretation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09574271261481044","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:18:55Z","timestamp":1787660335000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated interictal plasma CGRP in Meniere\u2019s disease: A headache-independent candidate biomarker distinguishing Meniere\u2019s disease from vestibular migraine"],"prefix":"10.1177","author":[{"given":"Yutong","family":"Bai","sequence":"first","affiliation":[{"name":"Jeonbuk National University Hospital & School of Medicine"},{"name":"Biomedical Research Institute of Jeonbuk National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ju","family":"Kang","sequence":"additional","affiliation":[{"name":"Jeonbuk National University Hospital & School of Medicine"},{"name":"Biomedical Research Institute of Jeonbuk National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1820-8419","authenticated-orcid":false,"given":"Juhee","family":"Chae","sequence":"additional","affiliation":[{"name":"Jeonbuk National University Hospital & School of Medicine"},{"name":"Biomedical Research Institute of Jeonbuk National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Dieterich","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-University"},{"name":"Ludwig-Maximilians-University"},{"name":"Munich Cluster for Systems Neurology (SyNergy)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kyung","family":"Chu","sequence":"additional","affiliation":[{"name":"Severance Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3174-1680","authenticated-orcid":false,"given":"Sun-Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Jeonbuk National University Hospital & School of Medicine"},{"name":"Biomedical Research Institute of Jeonbuk National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309123007"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11532-x"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25344"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1992.hed3206300.x"},{"key":"e_1_3_9_6_2","first-page":"814","article-title":"Vestibular function: migraine extends to the inner ear","volume":"93","author":"G\u00fcrkov R","year":"2014","unstructured":"G\u00fcrkov R, Ilgner J. 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