{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:30:12Z","timestamp":1788201012492,"version":"build-2803163510"},"reference-count":111,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2027,8,29]],"date-time":"2027-08-29T00:00:00Z","timestamp":1819497600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sagepub.com\/licence-information-for-chorus"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100014036","name":"Multidisciplinary University Research Initiative","doi-asserted-by":"publisher","award":["N00014-20-1-2163"],"award-info":[{"award-number":["N00014-20-1-2163"]}],"id":[{"id":"10.13039\/100014036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vestibular Research"],"abstract":"<jats:p>\n                    Hypoxia when breathing air with the percentage of inspired oxygen (% O\n                    <jats:sub>2<\/jats:sub>\n                    ) reduced has been shown to diminish sensory, motor, and cognitive function. We recently showed that hypoxia experienced while inspiring air with 15.4% O\n                    <jats:sub>2<\/jats:sub>\n                    decreased sensitivity to upward and downward motions (Z-Translations). Here, we follow-up with similar Z-Translation perceptual threshold testing in 5 patients with unilateral vestibular hypofunction. All testing was completed at an altitude of 820\u00a0ft (249\u00a0m). Each patient completed Z-Translation vestibular threshold testing with inspired % O\n                    <jats:sub>2<\/jats:sub>\n                    set to 20.9%, 17.9%, 16.6%, and 15.4% to mimic the effects of altitudes of 820\u00a0ft, 4000\u00a0ft, 6000\u00a0ft, or 8000\u00a0ft (249\u00a0m, 1219\u00a0m, 1828\u00a0m, or 2438\u00a0m), respectively. Z-Translation thresholds significantly increased in the hypoxic conditions (F (3,88) = 8.29,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 6.48 \u00d7 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    ). Further, greater reductions in peripheral oxygen saturation (SpO\n                    <jats:sub>2<\/jats:sub>\n                    ) significantly predicted higher Z-Translation thresholds (estimated slope = 0.67\u00a0cm\/s\/%, t (73.37) = \u22122.83,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.006). These results provide evidence that sensing whole-body motion is susceptible to hypoxia. Extra precautions and countermeasures may be warranted for people experiencing mild reductions in blood oxygenation \u2013 especially patients with vestibular hypofunction \u2013 while performing tasks that require balance and\/or accurate and precise spatial orientation.\n                  <\/jats:p>","DOI":"10.1177\/09574271261483520","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T12:19:04Z","timestamp":1788005944000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypoxia increases vertical translation thresholds in patients with unilateral vestibular hypofunction"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9200-9923","authenticated-orcid":false,"given":"Kyle A.","family":"Kainec","sequence":"first","affiliation":[{"name":"The Ohio State University Wexner Medical Center"},{"name":"Naval Medical Research Unit-Dayton"},{"name":"Leidos"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Oas","sequence":"additional","affiliation":[{"name":"Naval Medical Research Unit-Dayton"},{"name":"Leidos"},{"name":"Naval Aerospace Medical Research Laboratory, Oak Ridge Institute for Science and Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-315X","authenticated-orcid":false,"given":"Cora B.","family":"Cox","sequence":"additional","affiliation":[{"name":"Naval Medical Research Unit-Dayton"},{"name":"Leidos"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7692-181X","authenticated-orcid":false,"given":"Max A.","family":"Teaford","sequence":"additional","affiliation":[{"name":"University of Tennessee at Chattanooga"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle A.","family":"Pettijohn","sequence":"additional","affiliation":[{"name":"Naval Medical Research Unit-Dayton"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7212-337X","authenticated-orcid":false,"given":"Daniel M.","family":"Merfeld","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center"},{"name":"Naval Medical Research Unit-Dayton"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.019"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12060808"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-021-00796-3"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1383\/anes.2005.6.11.376"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201207-1323CI"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3357\/ASEM.3315.2012"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13728-014-0021-6"},{"key":"e_1_3_7_9_2","first-page":"1091","volume-title":"Fundamentals of aerospace medicine","author":"DeHart RL","year":"1996","unstructured":"DeHart RL (ed). 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