{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:00:53Z","timestamp":1778569253025,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82060205"],"award-info":[{"award-number":["82060205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Zunyi Science and Technology Plan Project","award":["Zun Shi Ke He HZ Zi [2023] 82"],"award-info":[{"award-number":["Zun Shi Ke He HZ Zi [2023] 82"]}]},{"name":"Zunyi Science and Technology Plan Project","award":["Zun Shi Ke He HZ Zi (2022) 423"],"award-info":[{"award-number":["Zun Shi Ke He HZ Zi (2022) 423"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Bio-Medical Materials and Engineering"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mesenchymal stem cells-derived exosomes, crucial in regenerative medicine, have been explored for their potential for the functional modi\ufb01cation of bone scaffolds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To design a functionally modified biomimetic nanohydroxyapatite using exosomes and explore its effects on bone regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A biomimetic nanohydroxyapatite (named as tHA) was fabricated as previous methods using a polydopamine (pDA) structure as a template, and exosomes (Exo) derived from periodontal ligament stem cells (PDLSCs) were used to functionally modify the tHA scaffold material through pDA. The effects of functional composite scaffold (tHA-Exo) on cells proliferation and osteogenic differentiation were investigated. Furthermore, their effect on bone regeneration was also evaluated in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Exosomes can be loaded onto the tHA via pDA and the tHA-Exo releases exosomes in a sustained and stable manner. tHA-Exo showed improved cytocompatibility compared to controls. Additionally, tHA-Exo significantly enhanced the proliferation and osteogenic differentiation of PDLSCs. More importantly, animal experiments have shown that tHA-Exo could dramatically promote bone regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The tHA nanoparticles, functionally modified by the PDLSCs-Exo through pDA, significantly promoted bone regeneration by improving its cytocompatibility and osteogenic potential, which could serve as a promising material for promoting bone regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09592989241301662","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T09:19:30Z","timestamp":1734081570000},"page":"98-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Polydopamine-functionalized nanohydroxyapatite coated exosomes with enhanced cytocompatibility and osteogenesis for bone regeneration"],"prefix":"10.1177","volume":"36","author":[{"given":"Mingli","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China"},{"name":"GuiZhou University Medical College, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gengchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulin","family":"Liu","sequence":"additional","affiliation":[{"name":"Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengcheng","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Liu","sequence":"additional","affiliation":[{"name":"GuiZhou University Medical College, Guiyang, China"},{"name":"Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22-0241"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_37_23"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-021-01607-z"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2020.06.033"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.03.018"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2021.01.043"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.2022041926"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2023.103013"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","DOI":"10.3390\/nano13121881","article-title":"Osteogenic potential of nano-hydroxyapatite and strontium-substituted nano-hydroxyapatite","volume":"13","author":"Kontogianni GI","year":"2023","unstructured":"Kontogianni GI, Coelho C, Gauthier R, et al. 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