{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:16:59Z","timestamp":1777465019126,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Bio-Medical Materials and Engineering"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Urethral stricture (US) is a common condition that considerably affects patients\u2019 quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to explore the adoption value of the extracellular vesicle (EV)- small intestinal submucosa (SIS) complex in the repair of USs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EVs were extracted from healthy male New Zealand white rabbits, and SIS was prepared using peracetic acid (PAA) oxidation and decellularization. The morphology and particle size of the prepared EV-SIS complex were evaluated using electron microscopy and qNano nanoparticle analyzer, and the labeled proteins of EVs were detected using Western blot method. EV-SIS the complex was implanted in a rabbit model of US, and urodynamic parameters were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The EV-SIS complex displayed a full morphology, intact membrane structure, and uniform particle size. The protein concentration of EVs in the complex was approximately 0.351\u2005\u00b5g\/\u00b5L, with a yield of approximately 1.86\u2005\u00b5g\/10\n                      <jats:sup>6<\/jats:sup>\n                      cells. The complex exhibited remarkable repair effects in the rabbit model of US, with bladder capacity, maximal urethral pressure, and minimal urethral pressure all markedly superior to those in the US group (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The EV-SIS complex demonstrates potential clinical value in the repair of USs, improving urodynamic parameters, and offering a promising therapeutic option for patients with US.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09592989241308802","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T02:26:54Z","timestamp":1736735214000},"page":"174-184","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Experimental study of extracellular vesicle-small intestine submucosa novel biological composite for urethral stricture repair and reconstruction"],"prefix":"10.1177","volume":"36","author":[{"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology Surgery, The Affiliated Hospital of Inner Mongolia Medical, Hohhot 010050, Inner Mongolia Autonomous Region, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, The Affiliated Hospital of Inner Mongolia Medical, Hohhot 010050, Inner Mongolia Autonomous Region, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buhe","family":"Siqin","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, The Affiliated Hospital of Inner Mongolia Medical, Hohhot 010050, Inner Mongolia Autonomous Region, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, The Affiliated Hospital of Inner Mongolia Medical, Hohhot 010050, Inner Mongolia Autonomous Region, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, The Affiliated Hospital of Inner Mongolia Medical, Hohhot 010050, Inner Mongolia Autonomous Region, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, The Affiliated Hospital of Inner Mongolia Medical, Hohhot 010050, Inner Mongolia Autonomous Region, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2018.0316"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003482"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9046430"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-022-01113-w"},{"key":"e_1_3_2_6_2","first-page":"3389","article-title":"Comparison of the diagnostic value of capsule endoscopy in two positions for esophageal lesions in the elderly","volume":"35","author":"Ya Y","year":"2019","unstructured":"Ya Y, Shi Z, Xue X, et al. Comparison of the diagnostic value of capsule endoscopy in two positions for esophageal lesions in the elderly. Acta Med Mediterr 2019; 35: 3389\u20133394.","journal-title":"Acta Med Mediterr"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-020-00237-z"},{"key":"e_1_3_2_8_2","article-title":"Urine-microenvironment-initiated composite hydrogel patch reconfiguration propels scarless memory repair and reinvigoration of the urethra","volume":"34","author":"Yang M","year":"2022","unstructured":"Yang M, Zhang Y, Fang C, et al. Urine-microenvironment-initiated composite hydrogel patch reconfiguration propels scarless memory repair and reinvigoration of the urethra. Adv Mater 2022; 34: e2109522.","journal-title":"Adv Mater"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-022-03154-z"},{"key":"e_1_3_2_10_2","first-page":"68","article-title":"Nano-carbon-based application of parecoxib sodium combined with hydromorphone in preventing anesthesia hyperalgesia caused by remifentanil after thyroidectomy","volume":"3","author":"Zhou J","year":"2022","unstructured":"Zhou J, Wu Z, Xu H, et al. Nano-carbon-based application of parecoxib sodium combined with hydromorphone in preventing anesthesia hyperalgesia caused by remifentanil after thyroidectomy. Cell Mol Biol 2022; 3: 68.","journal-title":"Cell Mol Biol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120651"},{"key":"e_1_3_2_12_2","first-page":"31","article-title":"Evaluation of the composition of the microbiota of the urethra in men with sexually transmitted infections","volume":"6","author":"Rakhmatulina MR","year":"2019","unstructured":"Rakhmatulina MR, Boldyreva MN, Lipova EV, et al. Evaluation of the composition of the microbiota of the urethra in men with sexually transmitted infections. Urologiia 2019; 6: 31\u201337.","journal-title":"Urologiia"},{"key":"e_1_3_2_13_2","first-page":"825","article-title":"microRNA-23B inhibits non-small cell lung cancer proliferation, invasion and migration via downregulation of RUNX2 and inhibition of Wnt\/\u0392-catenin signaling pathway","volume":"34","author":"Wang H","year":"2020","unstructured":"Wang H, Wang X, Fei J, et al. microRNA-23B inhibits non-small cell lung cancer proliferation, invasion and migration via downregulation of RUNX2 and inhibition of Wnt\/\u0392-catenin signaling pathway. J Biol Reg Homeos Agents 2020; 34: 825\u2013835.","journal-title":"J Biol Reg Homeos Agents"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/biot.202000082"},{"key":"e_1_3_2_15_2","article-title":"Exosomes-loaded electroconductive hydrogel synergistically promotes tissue repair after spinal cord injury via immunoregulation and enhancement of myelinated axon growth","volume":"9","author":"Fan L","year":"2022","unstructured":"Fan L, Liu C, Chen X, et al. Exosomes-loaded electroconductive hydrogel synergistically promotes tissue repair after spinal cord injury via immunoregulation and enhancement of myelinated axon growth. Adv Sci (Weinh) 2022; 9: e2105586.","journal-title":"Adv Sci (Weinh)"},{"key":"e_1_3_2_16_2","first-page":"91","article-title":"Defining the role of T lymphocytes in the immunopathogenesis of neuromyelitis optica spectrum disorder","volume":"29","author":"Fitzgerald D","year":"2020","unstructured":"Fitzgerald D, Laurent M, Funaro M, et al. Defining the role of T lymphocytes in the immunopathogenesis of neuromyelitis optica spectrum disorder. Discov Med 2020; 29: 91\u2013102.","journal-title":"Discov Med"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i7.1631"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/21501351211069559"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1713772"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.21957.1"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24384-2"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S342685"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112218"}],"container-title":["Bio-Medical Materials and Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09592989241308802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09592989241308802","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09592989241308802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:24:43Z","timestamp":1777382683000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09592989241308802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,12]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/09592989241308802"],"URL":"https:\/\/doi.org\/10.1177\/09592989241308802","relation":{},"ISSN":["0959-2989","1878-3619"],"issn-type":[{"value":"0959-2989","type":"print"},{"value":"1878-3619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,12]]}}}