{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:09:19Z","timestamp":1789207759297,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","issue":"4-5","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ministry of Education (MOE), Taiwan"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Bio-Medical Materials and Engineering"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergic conjunctivitis is an inflammatory disorder of the conjunctiva triggered by allergens. Although topical eye drops are widely used, their efficacy is limited by rapid precorneal clearance and low ocular bioavailability. Hyaluronic acid (HA)-based nanoparticles may prolong ocular residence time and improve drug delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to develop and evaluate chitosan- and polyethylenimine (PEI)-cross-linked HA nanoparticles to improve drug encapsulation efficiency and achieve sustained release of diclofenac sodium for allergic conjunctivitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      HA nanoparticles were prepared by EDC\/sulfo-NHS-mediated cross-linking with chitosan or PEI. Nanoparticle properties were characterized by FTIR,\n                      <jats:sup>1<\/jats:sup>\n                      H-NMR, DLS, and HRTEM. Encapsulation efficiency, in vitro drug release, and cytocompatibility in SIRC cells were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FTIR and\n                      <jats:sup>1<\/jats:sup>\n                      H-NMR analyses confirmed successful nanoparticle formation, cross-linking, and drug incorporation. H1P1-01DS exhibited a particle size of approximately 170\u2005nm and a significantly higher encapsulation efficiency (82.0%) than the HA-chitosan formulations. Drug release followed a biphasic profile, with H1P1-01DS achieving approximately 90% cumulative release within 180\u2005min, compared with 68\u201383% for HA-chitosan formulations. WST-1 assays demonstrated favorable cytocompatibility across all formulations, although cell viability decreased in a dose-dependent manner at higher concentrations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The HA-PEI nanoparticle formulation (H1P1-01DS) demonstrated sustained drug release, high encapsulation efficiency, and favorable biocompatibility, indicating its potential as a long-acting ocular drug delivery system for allergic conjunctivitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09592989261474686","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:07:10Z","timestamp":1786457230000},"page":"241-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyaluronic acid nanoparticle as drug delivery carrier for the treatment of allergic conjunctivitis"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8144-8522","authenticated-orcid":false,"given":"Chia-Wei","family":"Lin","sequence":"first","affiliation":[{"name":"Asia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-7689","authenticated-orcid":false,"given":"Wen-Pin","family":"Hu","sequence":"additional","affiliation":[{"name":"Asia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6201-2985","authenticated-orcid":false,"given":"Wen-Yu","family":"Su","sequence":"additional","affiliation":[{"name":"Asia University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.01006.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.280318"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-88317-3_2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03716.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.10.020"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4155\/tde.10.40"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","unstructured":"Mitra AK Mitra AK. 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