{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:19:09Z","timestamp":1777666749961,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>\n                    We utilized a mice model of Parkinsonism: (1) to evaluate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity; and (2) to evaluate whether manganese (Mn) exposure can affect MPTP-induced neurotoxicity. A 2 \u00d7 3 experimental design (MPTP \u00d7\u00b1 Mn) was as follows: SS, MPTP(-) \u00d7 Mn(-); SLMn, MPTP(-) \u00d7 low Mn(+); SHMn, MPTP(-) \u00d7 high Mn(+); MpS, MPTP(+) \u00d7 Mn(-); MpLMn, MPTP(+) \u00d7 low Mn(+); MpHMn, MPTP(+) \u00d7 high Mn(+). We administered MPTP (30 mg\/kg per day) to male C57BL\/6 mice intraperitoneally, once a day for 5 days. Subsequently, mice were treated with either 2 or 8 mg\/kg of MnCl\n                    <jats:sub>2<\/jats:sub>\n                    .4H\n                    <jats:sub>2<\/jats:sub>\n                    O intraperitoneally, once a day for 3 weeks.\n                  <\/jats:p>\n                  <jats:p>Blood and striatal Mn levels were elevated in the Mnexposed groups. The number of tyrosine hydroxylase (TH)-immunoreactive (ir) neurons in the substantia nigra pars compacta were decreased significantly in the MPTP-exposed groups. The densities of TH-ir axon terminals in caudate-putamen (CPU) were significantly decreased in the MPTP-treated groups. However, Mn treatment did not affect MPTP neurotoxicity. The densities of glial fibrillary acidic protein (GFAP)-ir astrocytes in the CPU or globus pallidus were significantly increased in the MPTP-treated groups. Concentrations of dopamine in the striatum were decreased significantly in the MPTP-exposed groups only, but Mn had no effect.<\/jats:p>","DOI":"10.1177\/0960327107070567","type":"journal-article","created":{"date-parts":[[2007,3,12]],"date-time":"2007-03-12T08:25:59Z","timestamp":1173687959000},"page":"203-211","source":"Crossref","is-referenced-by-count":10,"title":["Manganese does not alter the severe neurotoxicity of MPTP"],"prefix":"10.1177","volume":"26","author":[{"given":"S Y","family":"Baek","sequence":"first","affiliation":[{"name":"Department of Anatomy, Pusan National University Medical School, Busan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y H","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, School of Medicine and Paik Institute of Clinical Research, Inje University, Busan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S O","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pusan National University Medical School, Busan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C-R","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C I","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C S","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Park","sequence":"additional","affiliation":[{"name":"Occupational Safety and Health Research Institute, Incheon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-W","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dong-A University School of Medicine, Busan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C S","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Occupational Health, Catholic University of Daegu, Gyeongbuk, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,3,1]]},"reference":[{"key":"atypb1","first-page":"249","volume":"20","author":"Kim Y","year":"1999","journal-title":"Neurotoxicology"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10089"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.3.650"},{"key":"atypb4","first-page":"239","volume":"20","author":"Gorell JM","year":"1999","journal-title":"Neurotoxicology"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1017\/S0317167100030584","volume":"17","author":"Zayed J","year":"1990","journal-title":"Can J Neurol Sci"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.6.1173"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1275"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100039482"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.42.352"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2004.07.001"},{"key":"atypb11","first-page":"341","volume":"6","author":"Bonilla E","year":"1984","journal-title":"Neurobehav Toxicol Teratol"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(82)90055-5"},{"key":"atypb13","first-page":"75","volume":"3","author":"Gianutsos G","year":"1982","journal-title":"Neurotoxicology"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-9351(05)80017-9"},{"key":"atypb15","first-page":"19","volume":"7","author":"Yong VW","year":"1986","journal-title":"Neurotoxicology"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(84)90092-6"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316209"},{"key":"atypb18","first-page":"427","volume":"7","author":"Ali MM","year":"1985","journal-title":"Neurobehav Toxicol Teratol"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb01642.x"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1979.tb05267.x"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-813X(03)00033-0"},{"key":"atypb22","first-page":"13","volume":"5","author":"Barbeau A.","year":"1984","journal-title":"Neurotoxicology"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.9.1583"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.1.8"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20381"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.9.1385"},{"key":"atypb27","volume-title":"The mouse brain in stereotaxic coordinates","author":"Franklin KBJ","year":"1997"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1007\/BF00995386"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1006\/neur.1996.0041"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00571-4"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90112-N"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1981.tb01594.x"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1007\/BF01056081"},{"key":"atypb34","first-page":"17","volume":"2","author":"Bull RJ","year":"1978","journal-title":"Commun Psychopharmacol"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686083"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.4.1053"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327107070567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327107070567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:44:04Z","timestamp":1777448644000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327107070567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1177\/0960327107070567"],"URL":"https:\/\/doi.org\/10.1177\/0960327107070567","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}