{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:29:26Z","timestamp":1793161766502,"version":"4.5.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>1-Propanol and 2-propanol are isomers of an alcohol with three carbons. They are colorless liquids with a sweet odor. 1-Propanol is metabolized by alcohol dehydrogenase to propionic acid and presents with metabolic acidosis and elevated anion gap, whereas 2-propanol is metabolized by alcohol dehydrogenase to acetone and presents with rapidly developing (within 3\u20134\u00a0h after exposure) ketosis and ketonuria but without metabolic acidosis. We report a patient who simultaneously ingested a lethal dose of 1-propanol and 2-propanol as a hand disinfectant in hospital. The patient lost consciousness and stopped breathing within half an hour after ingestion. He was intubated and artificially ventilated. Initial laboratory results showed mixed acidosis with elevated anion gap, but ketonuria appeared only 12\u00a0h after admission and 6\u00a0h following the regaining of consciousness. Therefore, laboratory results in simultaneous poisoning with two isomers of alcohol are not just a sum of laboratory results obtained in isolated poisoning with each isomer because they influence each other\u2019s metabolism: 1-propanol retards the metabolism of 2-propanol to acetone. In conclusion, 1-propanol and 2-propanol poisoning presents early with mixed acidosis and elevated anion gap and only later with ketonuria.<\/jats:p>","DOI":"10.1177\/0960327107087794","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T18:54:58Z","timestamp":1206730498000},"page":"975-978","source":"Crossref","is-referenced-by-count":30,"title":["Poisoning with 1-propanol and 2-propanol"],"prefix":"10.1177","volume":"26","author":[{"given":"M","family":"Vujasinovi\u0107","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Topol\u0161ica Hospital,                         Topol\u0161ica, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ko\u010dar","sequence":"additional","affiliation":[{"name":"Department of Pulmology, Topol\u0161ica Hospital, Topolsica,                     Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Pulmology, Topol\u0161ica Hospital, Topolsica,                     Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bunc","sequence":"additional","affiliation":[{"name":"Department for Cardiology, University Medical Centre Ljubljana,                         Ljubljana, Slovenia; Medical Faculty, Institute for Pathophysiology,                         Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Brvar","sequence":"additional","affiliation":[{"name":"Medical Faculty, Institute for Pathophysiology, Ljubljana, Slovenia;                         Poison Control Centre, University Medical Centre Ljubljana, Ljubljana,                         Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"atypb2","first-page":"491","volume-title":"Clinical management of poisoning and drug overdose","author":"Winchester JF","year":"1998","edition":"3"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1080\/00022470.1974.10470005"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90456-4"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0735-6757(92)90179-2"},{"key":"atypb7","first-page":"1447","volume-title":"Goldfrank\u2019s toxicologic emergencies","author":"Wiener SW","year":"2006","edition":"8"},{"key":"atypb8","first-page":"889","volume-title":"Critical care toxicology: diagnosis and management of the critically poisoned patients","author":"Jolliff HA","year":"2005","edition":"1"},{"key":"atypb9","first-page":"282","volume":"46","author":"Trullas JC","year":"2004","journal-title":"Vet Hum Toxicol"},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.arcped.2004.04.023","volume":"11","author":"Brayer C","year":"2004","journal-title":"Arch Pediatr"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000094205.26168.43"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.34938"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-100102881"},{"key":"atypb14","first-page":"588","volume":"57","author":"Mankowski W","year":"2000","journal-title":"Przegl Lek"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/24.7.664"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-200008000-00005"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.3109\/15563659109038593"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.3109\/15563659309000415"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.3109\/15563658308990615"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.3109\/15563658209025731"},{"key":"atypb21","first-page":"110","volume":"24","author":"Buckley BM","year":"1986","journal-title":"Prescr J"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1042\/bj1000034"}],"container-title":["Human &amp; 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