{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:18:48Z","timestamp":1777666728634,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>Bromism, chronic bromide intoxication, can be caused by a variety of medicines, but bromism due to pain-relieving injectable medications has not been reported. In this study, the methods used were internet searching on bromide-containing injectables available in Taiwan and the first case report of bromism due to mixed-formulated injectable medication. Many analgesic\/antipyretic and antihistamine injections containing bromides are still being used in Taiwan. They contain sodium bromide up to 1000\u00a0mg\/ampoule or calcium bromide up to 800\u00a0mg\/amp. A 25-year-old female suffered from forgetfulness and unstable gait after long-term frequent injections of a preparation to relieve head and neck pain. Blood tests showed hyperchloremia (171\u00a0mEq\/L) and a negative anion gap (\u221248.7\u00a0mEq\/L). Serum bromide measured 2150\u00a0mg\/L. She recovered completely in 3\u00a0days with saline treatment. Many bromide-containing injections are still being used in Taiwan. Clinicians should keep alert on this issue to avoid iatrogenic bromism or making misdiagnoses.<\/jats:p>","DOI":"10.1177\/0960327107087797","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T18:54:58Z","timestamp":1206730498000},"page":"971-973","source":"Crossref","is-referenced-by-count":9,"title":["Bromism caused by mix-formulated analgesic injectables"],"prefix":"10.1177","volume":"26","author":[{"given":"PF","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Neurology, Taichung Veterans                         General Hospital, Taichung, Taiwan, Republic of China; Department of                         Neurology, National Yang-Ming University, Taipei, Taiwan, Republic of China;                         Graduate Institute of Biomedicine and Biomedical Technology, National Chi                         Nan University, Nantou Hsien, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YT","family":"Tsan","sequence":"additional","affiliation":[{"name":"Department of Emergency, Division of Toxicology, Taichung Veterans                         General Hospital, Taichung, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DZ","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Emergency, Division of Toxicology, Taichung Veterans                         General Hospital, Taichung, Taiwan, Republic of China; Division of                         Environmental and Occupational Medicine, National Yang-Ming University,                         Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CL","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Division of Toxicology, Taichung Veterans                         General Hospital, Taichung, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YC","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Neurology, Taichung Veterans                         General Hospital, Taichung, Taiwan, Republic of China; Department of                         Neurology, National Yang-Ming University, Taipei, Taiwan, Republic of                     China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MH","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Neurology, Taichung Veterans                         General Hospital, Taichung, Taiwan, Republic of China; Department of                         Neurology, National Yang-Ming University, Taipei, Taiwan, Republic of                     China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)90441-7"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/36.8.1399"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-199708000-00008"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00042-9"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/36.8.1470"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1927.02680520003002"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03440080099031"},{"key":"atypb8","first-page":"509","volume":"98","author":"Deleu D","year":"1985","journal-title":"Acta Gastroenterol Belg"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1159\/000169056"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1984.00350140236034"},{"key":"atypb11","first-page":"307","volume":"28","author":"Postma CT","year":"1985","journal-title":"Neth J Med"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1159\/000168457"},{"key":"atypb13","first-page":"852","volume":"26","author":"Bonnotte B","year":"1997","journal-title":"Presse Med"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.3109\/15563659709001219"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.37.788"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.3143\/geriatrics.38.700"},{"key":"atypb17","first-page":"367","volume":"39","author":"Makita Y","year":"1999","journal-title":"Rinsho Shinkeigaku"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1007\/s0054010050088"},{"key":"atypb19","first-page":"459","volume":"22","author":"Hung YM","year":"2003","journal-title":"Hum Exp Toxicol"}],"container-title":["Human &amp; 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