{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:21:26Z","timestamp":1777666886170,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>The influence of melatonin, curcumin, quercetin, and resveratrol pretreatment on ferric nitrilotriacetate (Fe-NTA)-induced oxidative renal damage was studied. Male Wistar rats were treated orally once daily for 3\u00a0days with melatonin (10\u00a0mg\/kg), curcumin (50\u00a0mg\/kg), quercetin (15\u00a0mg\/kg), and resveratrol (10\u00a0mg\/kg). One hour after the last dose of antioxidants, a single dose of Fe-NTA was administered (8\u00a0mg of Fe\/kg body weight, i.p.) to pre-treated animals. Twenty-four hours after Fe-NTA administration, the lipid peroxidation (LP), reduced glutathione (GSH), catalase (CAT), and glutathione peroxidase (GSH-Px) were estimated in kidney homogenates. Iron, zinc, and copper concentrations were estimated in kidney tissue. Administration of Fe-NTA to rats induced renal LP (170%, P\u00a0&lt;\u00a00.001) and inhibited catalase (78%, P\u00a0&lt;\u00a00.05) in the kidney. The oral pretreatment with melatonin, curcumin, quercetin, and resveratrol each one was effective in decreasing the Fe-NTA-induced LP ( P\u00a0&lt;\u00a00.001); however, it did not influence the FeNTA-induced inhibition of renal CAT activity. No changes were found in renal GSH level and GSH-Px activity compared to control animals. The pretreatment with antioxidants did not affect the increase in renal iron content, blood urea nitrogen\/creatinine ratio, and relative kidney weight of FeNTA-intoxicated rats. The results indicate that the pretreatment with natural antioxidants, curcumin, melatonin, quercetin, and resveratrol, significantly and equally suppressed lipid peroxidation induced by Fe-NTA but had no effect on other markers of FeNTA nephrotoxicity and iron deposition in kidneys.<\/jats:p>","DOI":"10.1177\/0960327108094508","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T08:18:38Z","timestamp":1218010718000},"page":"347-353","source":"Crossref","is-referenced-by-count":26,"title":["Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats"],"prefix":"10.1177","volume":"27","author":[{"given":"V","family":"Eybl","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Medicine in Pilsen, Karlovarsk\u00e1 48, 301 66 Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kotyzov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Medicine in Pilsen, Karlovarsk\u00e1 48, 301 66 Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"\u010cern\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Medicine in Pilsen, Karlovarsk\u00e1 48, 301 66 Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Koutensk\u00fd","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Medicine in Pilsen, Karlovarsk\u00e1 48, 301 66 Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(85)90326-6"},{"key":"atypb2","first-page":"1867","volume":"47","author":"Li JL","year":"1987","journal-title":"Cancer Res"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(88)90028-2"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(90)90097-H"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1181"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1996.tb03617.x"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.07.013"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.15095"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.02.019"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.05.011"},{"key":"atypb11","first-page":"23","volume":"5","author":"Kotyzova D","year":"2004","journal-title":"Biomarkers & Environment"},{"key":"atypb12","first-page":"349","volume-title":"Phytopharmaceuticals in cancer chemoprevention.","author":"Aggarwal BB","year":"2005"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.09.041"},{"key":"atypb14","first-page":"229","volume":"41","author":"Reiter RJ","year":"1998","journal-title":"Proc West Pharmacol Soc"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1080\/1071576021000016463"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.08.105"},{"key":"atypb17","first-page":"2783","volume":"24","author":"Aggarwal BB","year":"2004","journal-title":"Anticancer Res"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(99)00100-6"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.09.006"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.8.2090"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1081\/DCT-120030729"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200103000-00004"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02919.x"},{"key":"atypb24","first-page":"663","volume":"95","author":"Awai M","year":"1979","journal-title":"Am J Pathol"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"key":"atypb26","first-page":"673","volume-title":"Methods of Enzymatic Analysis","author":"Aebi H","year":"1972"},{"key":"atypb27","first-page":"444","volume":"12","author":"G\u00fcnzler VA","year":"1974","journal-title":"Z Klin Chem Klin Biochem"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(68)90092-4"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.10070"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2004.00113.x"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.05.005"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.07.012"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.01.011"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(92)90181-G"},{"key":"atypb35","first-page":"1","volume":"409","author":"National Toxicology Program","year":"1992","journal-title":"Natl Toxicol Program Tech Rep Ser"},{"key":"atypb36","first-page":"1","volume":"427","year":"1993","journal-title":"Natl Toxicol Program Tech Rep Ser"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh263"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2006.07.060"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2001.300301.x"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1080\/08860220500531112"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(98)00008-8"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1191\/0960327104ht427oa"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.04.018"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.01.011"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.12.041"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110787"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90371-3"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/46.1.166"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1191\/0960327102ht273oa"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327108094508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327108094508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:44:39Z","timestamp":1777448679000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327108094508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1177\/0960327108094508"],"URL":"https:\/\/doi.org\/10.1177\/0960327108094508","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}