{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:21:41Z","timestamp":1777666901318,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>Long-term treatment with antipsychotic medications alters the regional density of several of the neurotransmitter receptors that mediate cocaine toxicity. However, the effect of either up- or down-regulation of the neurotransmitter receptors on cocaine toxicity is unknown. In this study, we determined if subacute administration of the atypical antipsychotic ziprasidone altered the toxic effects of cocaine in mice. Ziprasidone (4\u00a0mg\/kg) or placebo was administered to the first two groups of CF-1 mice for 10\u00a0days and, then on day 10, an estimated LD50 dose of cocaine (102\u00a0mg\/kg) was given to these mice. In a third group, in order to produce a ziprasidone withdrawal state, we administered ziprasidone for 10\u00a0days, followed by no treatment for 2\u00a0days before cocaine administration. There was no significant difference among the three groups in overall survival: 63% in the treatment group, 60% in the withdrawal group, and 80% in the placebo group. Survival time was significantly shorter for the withdrawal group than for the control group. Our study may have been limited by lower than expected serum ziprasidone concentrations and lower than expected lethality from cocaine. However, our findings suggest that administration of an atypical antipsychotic for 10\u00a0days may increase the toxic effects of cocaine.<\/jats:p>","DOI":"10.1177\/0960327108095471","type":"journal-article","created":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T10:31:45Z","timestamp":1221042705000},"page":"499-503","source":"Crossref","is-referenced-by-count":2,"title":["Administration of ziprasidone for 10\u00a0days increases cocaine toxicity in mice"],"prefix":"10.1177","volume":"27","author":[{"given":"K","family":"Heard","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Emergency Medicine, University of Colorado School of Medicine, Denver, Colorado, USA; Denver Health and Hospitals, Rocky Mountain Poison and Drug Center, Denver, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Krier","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine, Denver, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NR","family":"Zahniser","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Colorado School of Medicine, Denver, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01130-7"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1016-3"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.052597"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00631-8"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00106-X"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450190043026"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/BF01245166"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(90)90071-O"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0736-4679(89)90011-5"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2005.tb01535.x"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1097\/01.ftd.0000150879.36296.4d"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1007\/BF03160899"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000650"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02141-7"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1007\/s002130051122"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245606"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01188-8"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050198"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050138"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244649"},{"key":"atypb21","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0022-3565(25)10934-8","volume":"262","author":"Howell LL","year":"1992","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327108095471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327108095471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:44:44Z","timestamp":1777448684000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327108095471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1177\/0960327108095471"],"URL":"https:\/\/doi.org\/10.1177\/0960327108095471","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}