{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:21:47Z","timestamp":1777666907118,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2008,7]]},"abstract":"\n Sibutramine is known to induce cardiovascular side effects such as tachycardia, vasodilation, and hypertension. The present study was aimed to examine the effects of sibutramine on action potential of guinea pig papillary muscle, recombinant hERG currents (I\n hERG<\/jats:sub>\n ), and inward currents (I\n Na<\/jats:sub>\n and I\n Ca<\/jats:sub>\n ) of rat ventricular myocytes. Sibutramine at 30\u00a0\u03bcg\/mL induced a shortening of action potential duration (APD) of guinea pig papillary muscle; on average, APD\n 30<\/jats:sub>\n and APD\n 90<\/jats:sub>\n were shortened by 23% and 17% at a stimulation rate of 1\u00a0Hz, respectively. Sibutramine suppressed the following currents: I\n hERG<\/jats:sub>\n (IC\n 50<\/jats:sub>\n :2.408\u00a0\u00b1\u00a00.5117\u00a0\u03bcg\/mL), L-type Ca current (IC\n 50<\/jats:sub>\n :2.709 \u00b1 0.4701\u00a0\u03bcg\/mL), and Na current (IC\n 50<\/jats:sub>\n :7.718\u00a0\u00b1\u00a01.7368\u00a0\u03bcg\/mL). Sibutramine blocked I\n hERG<\/jats:sub>\n , I\n Ca<\/jats:sub>\n , and I\n Na<\/jats:sub>\n in a concentration-dependent manner. In conclusion, sibutramine exerted a shortening effect on APD in guinea pig papillary muscle through its more powerful blocking effects on I\n Ca<\/jats:sub>\n and I\n Na<\/jats:sub>\n rather than I\n hERG<\/jats:sub>\n .\n <\/jats:p>","DOI":"10.1177\/0960327108095991","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T09:03:22Z","timestamp":1222851802000},"page":"553-558","source":"Crossref","is-referenced-by-count":4,"title":["Electrophysiological safety of sibutramine HCl"],"prefix":"10.1177","volume":"27","author":[{"given":"KS","family":"Kim","sequence":"first","affiliation":[{"name":"Department of pharmacology and National Research Laboratory, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Yuseong, Daejeon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SJ","family":"Park","sequence":"additional","affiliation":[{"name":"Department of pharmacology and National Research Laboratory, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Yuseong, Daejeon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HA","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of pharmacology and National Research Laboratory, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Yuseong, Daejeon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DK","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, Konyang University College of Medicine, Daejeon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EJ","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of pharmacology and National Research Laboratory, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Yuseong, Daejeon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789x.2000.00020.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1191\/0960327105ht510oa"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18319"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.124403"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(88)90003-6"},{"key":"atypb6","first-page":"345","volume":"127","author":"Abolfathi Z","year":"2004","journal-title":"J Pharm Pharm Sci"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00846-5"}],"container-title":["Human & Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327108095991","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327108095991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:44:45Z","timestamp":1777448685000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327108095991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1177\/0960327108095991"],"URL":"https:\/\/doi.org\/10.1177\/0960327108095991","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}