{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:20:22Z","timestamp":1777666822349,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2008,10]]},"abstract":"\n Chronic exposure to chloroform (CHCl\n 3<\/jats:sub>\n ) induces renal neoplasms in rodents and may be carcinogenic in humans, but studies on chronic CHCl\n 3<\/jats:sub>\n deposition in the human body have not been performed. In this study, we examined 27 hemodialysis patients with renal cystic diseases including acquired cystic disease of the kidney (ACDK) accompanied by renal tumors at high frequency. Intracystic and serum CHCl\n 3<\/jats:sub>\n concentrations were determined using a headspace gas chromatography\/mass spectrometry analysis. CHCl\n 3<\/jats:sub>\n was not detected in the serum in any cases, but levels ranging from <0.1 to 0.659\u00a0mg\/L were found in the cyst fluid in most cases, including patients with ACDK and autosomal dominant polycystic kidney disease. Because intracystic CHCl\n 3<\/jats:sub>\n deposition was not confined to ACDK cases, we were unable to evaluate the relationship between CHCl\n 3<\/jats:sub>\n accumulation and carcinogenesis in ACDK. However, our results suggest that compounds such as CHCl\n 3<\/jats:sub>\n accumulate in renal cyst fluid in hemodialysis patients with renal cystic diseases.\n <\/jats:p>","DOI":"10.1177\/0960327108096112","type":"journal-article","created":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T08:12:31Z","timestamp":1227859951000},"page":"769-772","source":"Crossref","is-referenced-by-count":0,"title":["Chloroform deposition in renal cyst fluid of hemodialysis patients with renal cystic disorders"],"prefix":"10.1177","volume":"27","author":[{"given":"F","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Urology, Tokyo Women\u2019s Medical University Medical Center East, Tokyo, Japan; Division of Renal Surgery and Transplantation, Department of Urology, Jichi Medical University, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Tokyo Women\u2019s Medical University Medical Center East, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Ohsaka","sequence":"additional","affiliation":[{"name":"Department of Urology, Tokyo Women\u2019s Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Yagisawa","sequence":"additional","affiliation":[{"name":"Division of Renal Surgery and Transplantation, Department of Urology, Jichi Medical University, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Urology, Tokyo Women\u2019s Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Urology, Tokyo Women\u2019s Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,10,1]]},"reference":[{"key":"atypb1","first-page":"830","volume-title":"Adult and pediatric urology","author":"Lippert MC","year":"2002","edition":"4"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(85)90200-3"},{"key":"atypb3","first-page":"741","volume-title":"Advances in the prevention of occupational respiratory disease.","author":"Nagano K","year":"1998"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(97)00225-X"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00058-1"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1990.9936712"},{"key":"atypb7","first-page":"1757","volume-title":"Campbell\u2019s urology","author":"Glassberg KI","year":"1998","edition":"7"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00380765"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199005050-00005"},{"key":"atypb10","first-page":"370","volume":"85","author":"Brugnone F","year":"1994","journal-title":"Med Lav"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1994.1138"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1159\/000044995"}],"container-title":["Human & Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327108096112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327108096112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:44:24Z","timestamp":1777448664000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327108096112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1177\/0960327108096112"],"URL":"https:\/\/doi.org\/10.1177\/0960327108096112","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}