{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:21:47Z","timestamp":1777666907930,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>\n                    We examined the effect of a nutrient mixture (NM) that contains lysine, proline, ascorbic acid, and green tea extract in mice treated with carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ), a model of liver injury in which free radical, oxidative stress, and cytokine production are closely linked. Seven-week-old male Imprinting Control Region (ICR) mice were divided into four groups (A\u2013D) of five animals each. Groups A and C mice were fed a regular diet for 2\u00a0weeks, whereas groups B and D mice were supplemented with 0.5% NM (w\/w) during that period. Groups A and B received corn oil i.p., whereas groups C and D received CCl\n                    <jats:sub>4<\/jats:sub>\n                    (25\u00a0\u03bcL\/kg, in corn oil, i.p.). All animals were killed 24\u00a0h after CCl\n                    <jats:sub>4<\/jats:sub>\n                    administration, serum was collected to assess liver and kidney functions, and livers and kidneys were excised for histology. Mean serum aspartate aminotransferase and alanine aminotransferase were comparable in groups A and B, increased markedly in group C, and significantly lowered in group D compared with group C. CCl\n                    <jats:sub>4<\/jats:sub>\n                    had no significant effect on renal markers (blood urea nitrogen [BUN], creatinine, and BUN\/creatinine ratio). CCl\n                    <jats:sub>4<\/jats:sub>\n                    administration caused an intense degree of liver necrosis that was less severe in the NM fed group D. These results indicate that NM could be a useful supplement in preventing acute chemical-induced liver toxicity.\n                  <\/jats:p>","DOI":"10.1177\/0960327108096851","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T09:03:22Z","timestamp":1222851802000},"page":"559-566","source":"Crossref","is-referenced-by-count":9,"title":["A nutrient mixture suppresses carbon tetrachloride\u2013induced acute hepatic toxicity in ICR mice"],"prefix":"10.1177","volume":"27","author":[{"given":"MW","family":"Roomi","sequence":"first","affiliation":[{"name":"Dr Rath Research Institute, Santa Clara, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kalinovsky","sequence":"additional","affiliation":[{"name":"Dr Rath Research Institute, Santa Clara, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NW","family":"Roomi","sequence":"additional","affiliation":[{"name":"Dr Rath Research Institute, Santa Clara, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Dr Rath Research Institute, Santa Clara, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Rath","sequence":"additional","affiliation":[{"name":"Dr Rath Research Institute, Santa Clara, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Niedzwiecki","sequence":"additional","affiliation":[{"name":"Dr Rath Research Institute, Santa Clara, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(00)00004-2"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)01167-X"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.3109\/10408447309082019"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250125"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1080\/01926230590881808"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(89)90050-8"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1993.1069"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(03)00250-3"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.12.025"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.12.023"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(01)00473-5"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(01)00429-2"},{"key":"atypb13","first-page":"369","volume":"11","author":"Ademuyiwa O","year":"1994","journal-title":"Hum Exp Toxicol"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(00)00098-3"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.3.742"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2006.12.016"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i24.3924"},{"key":"atypb18","first-page":"807","volume":"14","author":"Roomi MW","year":"2005","journal-title":"Oncol Rep"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1080\/01902140601098552"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3180308489"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000179432.73007.45"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1177\/0960327108090276"},{"key":"atypb23","first-page":"43","volume":"2","author":"Gonskii I","year":"1996","journal-title":"Patol Fiziol Eksp Ter"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(95)00064-9"},{"key":"atypb25","author":"Maksimchik YZ","year":"2007","journal-title":"Cell Biochem Funct"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh120"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1007\/BF02698042"},{"key":"atypb28","first-page":"17","volume":"7","author":"Rath M","year":"1992","journal-title":"Orthomol Med"},{"key":"atypb29","first-page":"213","volume":"21","author":"Kawakami S","year":"2001","journal-title":"Anticancer Res"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1177\/172460089901400413"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101143200"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1201\/9780203907993"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.4993\/acrt.12.146"},{"key":"atypb34","first-page":"37","volume":"2","author":"Netke SP","year":"2003","journal-title":"Res Commun Pharmacol Toxicol"}],"container-title":["Human &amp; 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