{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:34:46Z","timestamp":1791297286330,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p>\n                    The effect of fendiline on cytosolic free Ca\n                    <jats:sup>2+<\/jats:sup>\n                    concentrations ([Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    ) and proliferation has not been explored in human oral cancer cells. This study examined whether fendiline altered Ca\n                    <jats:sup>2+<\/jats:sup>\n                    levels and caused cell death in OC2 human oral cancer cells. [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    and cell viability were measured using the fluorescent dyes fura-2 and WST-1, respectively. Fendiline at concentrations above 10\u00a0\u03bcM increased [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    in a concentration-dependent manner. The Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signal was reduced partly by removing extracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    . The fendiline-induced Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx was sensitive to blockade of L-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel blockers. In Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -free medium, after pretreatment with 50\u00a0\u03bcM fendiline, 1\u00a0\u03bcM thapsigargin (an endoplasmic reticulum Ca\n                    <jats:sup>2+<\/jats:sup>\n                    pump inhibitor)-induced [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    rises were inhibited; and conversely, thapsigargin pretreatment nearly abolished fendiline-induced [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    rises. Inhibition of phospholipase C with 2\u00a0\u03bcM U73122 did not change fendiline-induced [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    rises. At concentrations between 5 and 25\u00a0\u03bcM, fendiline killed cells in a concentration-dependent manner. The cytotoxic effect of 15\u00a0\u03bcM fendiline was not reversed by prechelating cytosolic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    with BAPTA\/AM. Collectively, in OC2 cells, fendiline induced [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    rises by causing Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release from the endoplasmic reticulum and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx from L-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels. Furthermore, fendiline-caused cytotoxicity was not via a preceding [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    rise.\n                  <\/jats:p>","DOI":"10.1177\/0960327108097436","type":"journal-article","created":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T13:38:31Z","timestamp":1241185111000},"page":"41-48","source":"Crossref","is-referenced-by-count":23,"title":["Fendiline-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in human oral cancer cells"],"prefix":"10.1177","volume":"28","author":[{"given":"CC","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nursery, Tzu Hui Institute of Technology; Pingtung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CJ","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JS","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yongkang Veterans Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SI","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IS","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JY","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CT","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PL","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CR","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,5,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1185\/03007999109111663"},{"key":"atypb2","first-page":"103","volume":"5","author":"Bayer 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