{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:11:13Z","timestamp":1791130273988,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>We conducted a multicenter prospective study to assess the effects of occupational exposure to ethylenebisdithiocarbamate fungicides and\/or other pesticides on self-reported asthma and asthmatic symptoms. This multicenter study was conducted among 248 workers exposed to pesticides and 231 non-exposed workers from five field studies. The five field studies were carried out in The Netherlands, Italy, Finland, and two studies in Bulgaria. Subjects constituting this cohort completed a self-administered questionnaire at baseline (before the start of exposure). Ethylenethiourea in urine was determined to assess exposure to ethylenebisdithiocarbamates. In multivariate analyses adjusted for all potential confounders (age, education, residence, smoking, gender, and field study), we found inverse associations, all not statistically significant, between occupational exposure to pesticides and asthma diagnosis (OR 0.41; 95% CI 0.15\u20131.11), complains of chest tightness (OR 0.60; 95% CI 0.36\u20131.02), wheeze (OR 0.56; 95% CI 0.32\u20130.98), asthma attack (OR 0.52; 95% CI 0.12\u20132.25), and asthma medication (OR 0.79; 95% CI 0.25\u20132.53). Furthermore, we reported null associations for multivariate analysis using ethylenethiourea as determinant for exposure. Although exposure to pesticides remains a potential health risk, our results do not suggest an association between exposure to ethylenebisdithiocarbamates and\/or other pesticides used in our study on asthma and asthmatic symptoms.<\/jats:p>","DOI":"10.1177\/0960327108100001","type":"journal-article","created":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T08:03:16Z","timestamp":1227859396000},"page":"721-727","source":"Crossref","is-referenced-by-count":15,"title":["Asthmatic symptoms after exposure to ethylenebisdithiocarbamates and other pesticides in the Europit field studies"],"prefix":"10.1177","volume":"27","author":[{"given":"D","family":"Boers","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Maastricht University, The Netherlands; currently employed at Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"van Amelsvoort","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Maastricht University, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Colosio","sequence":"additional","affiliation":[{"name":"International Centre for Pesticides and Health Risk Prevention, University Hospital L. Sacco, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Corsini","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fustinoni","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, University of Milan and Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Campo","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, University of Milan and Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bosetti","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"La Vecchia","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d, Milan, Italy; Istituto di Statistica Medica e Biometria, University of Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Vergieva","sequence":"additional","affiliation":[{"name":"National Centre of Public Health Protection, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tarkowski","sequence":"additional","affiliation":[{"name":"Department of Immunotoxicology, Nofer Institute of Occupational Medicine, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Liesivuori","sequence":"additional","affiliation":[{"name":"Finnish Institute of Occupational Health, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Steerenberg","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment, Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"van Loveren","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Department of Health Risk Analyses and Toxicology, Maastricht University, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"atypb1","unstructured":"1 WHO. 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