{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:23:22Z","timestamp":1777667002677,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>\n                    The athletic performance supplement industry is a multibillion-dollar business and one popular category claims to increase nitric oxide (NO) production. We report three patients presenting to the emergency department with adverse effects. A 33-year-old man presented with palpitations, dizziness, vomiting, and syncope, after the use of NO\n                    <jats:sub>2<\/jats:sub>\n                    platinum. His examination and electrocardiogram (ECG) were normal. The dizziness persisted, requiring admission overnight. A 21-year-old man with palpitations and near syncope had used a \"nitric oxide\" supplement. He was tachycardic to 115 bpm with otherwise normal examination. Laboratory values including methemoglobin, and ECG were unremarkable. He was treated with 1 L of saline with no change in heart rate. He was admitted for observation. A 24-year-old man presented after taking NO-Xplode with palpitations and a headache. His examination, laboratory values, and ECG were normal. He was discharged. The purported active ingredient in these products is arginine \u03b1-ketoglutarate (AAKG), which is claimed to increase NO production by supplying the precursor L-arginine. The symptoms could be due to vasodilation from increased levels of NO, though other etiologies cannot be excluded. AAKG containing supplements may be associated with adverse effects requiring hospital admission.\n                  <\/jats:p>","DOI":"10.1177\/0960327109104498","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T11:24:29Z","timestamp":1253013869000},"page":"259-262","source":"Crossref","is-referenced-by-count":13,"title":["Adverse effects associated with arginine \u03b1-ketoglutarate containing supplements"],"prefix":"10.1177","volume":"28","author":[{"given":"JM","family":"Prosser","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine and Division of Toxicology, New York City Poison Center, New York University School of Medicine, New York, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Majlesi","sequence":"additional","affiliation":[{"name":"North Shore University Hospital, Manhasset, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GM","family":"Chan","sequence":"additional","affiliation":[{"name":"North Shore University Hospital, Manhasset, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Division of Toxicology, St. Barnabas Hospital, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RS","family":"Hoffman","sequence":"additional","affiliation":[{"name":"lDepartment of Emergency Medicine and Division of Toxicology, New York City Poison Center, New York University School of Medicine, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LS","family":"Nelson","sequence":"additional","affiliation":[{"name":"lDepartment of Emergency Medicine and Division of Toxicology, New York City Poison Center, New York University School of Medicine, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,9,15]]},"reference":[{"key":"atypb1","volume-title":"Health and personal care stores: 2002","author":"US Census Bureau."},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1123\/ijsn.4.4.320"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1123\/ijsn.9.4.416"},{"key":"atypb4","unstructured":"http:\/\/www.mri-performance.com\/ [accessed 11.06.08]."},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292706"},{"key":"atypb6","unstructured":"http:\/\/www.wada-ama.org\/en\/index.ch2 [accessed 11.06.08]."},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199607000-00023"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00257-9"},{"key":"atypb9","unstructured":"http:\/\/www.ironmagazine.com\/review58.html [accessed 11.06.08]."},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2006.06.003"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.01.022"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327109104498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327109104498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:45:07Z","timestamp":1777448707000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327109104498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1177\/0960327109104498"],"URL":"https:\/\/doi.org\/10.1177\/0960327109104498","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}