{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:30:07Z","timestamp":1780511407381,"version":"3.54.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>This study was conducted to characterize blood and urinary biochemistry, and renal morphology, after single or 1-week repeated dosing of mice with the polyene macrolide antibiotic, amphotericin B (AMB). AMB was intravenously administered to mice at 2 or 4 mg\/kg for the single-dose experiment or once daily at 1 or 2 mg\/kg for 1 week for the repeated-dose experiment. The most prominent histopathological findings included necrosis of the tubular epithelial cells in the thick ascending limb of Henle\u2019s loop in the renal outer medulla at a single dose of 2 or 4 mg\/kg, and the severity of the lesion was dose-dependent. Blood chemistry and urinalysis revealed several changes suggestive of renal dysfunction such as reduction of plasma filtration ability (increases in plasma creatinine and blood urea nitrogen, a decrease in creatinine clearance) and polyuria accompanied with dehydration (decrease in renal water reabsorption, increases in plasma total protein and albumin) at a dose of 4 mg\/kg in the single-dose experiment. Among the parameters analyzed, urinary lactate dehydrogenase was the most sensitive and reliable parameter for the prediction of AMB-induced nephrotoxicity in mice. These data provided comprehensive information on the nephrotoxicity of AMB and indicate useful markers for the sensitive detection of AMB-induced renal injury in mice.<\/jats:p>","DOI":"10.1177\/0960327109105404","type":"journal-article","created":{"date-parts":[[2009,8,6]],"date-time":"2009-08-06T21:26:01Z","timestamp":1249593961000},"page":"293-300","source":"Crossref","is-referenced-by-count":30,"title":["Amphotericin B-induced nephrotoxicity: characterization of blood and urinary biochemistry and renal morphology in mice"],"prefix":"10.1177","volume":"28","author":[{"given":"Y.","family":"Tonomura","sequence":"first","affiliation":[{"name":"Drug Safety Evaluation, Developmental Research Laboratories, Toyonaka, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Drug Safety Evaluation, Developmental Research Laboratories, Toyonaka, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kondo","sequence":"additional","affiliation":[{"name":"Drug Safety Evaluation, Developmental Research Laboratories, Toyonaka, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Itoh","sequence":"additional","affiliation":[{"name":"Drug Safety Evaluation, Developmental Research Laboratories, Toyonaka, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Drug Safety Evaluation, Developmental Research Laboratories, Toyonaka, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Uehara","sequence":"additional","affiliation":[{"name":"Drug Safety Evaluation, Developmental Research Laboratories, Toyonaka, Osaka, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Baba","sequence":"additional","affiliation":[{"name":"Drug Safety Evaluation, Developmental Research Laboratories, Toyonaka, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,8,6]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01572.x"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1681\/ASN.V62154","volume":"6","author":"Sawaya, BP","year":"1995","journal-title":"J Am Soc Nephrol"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196801182780302"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1979.03630380064021"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115240"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.186"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00583542"},{"key":"atypb8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1681\/ASN.V5168","volume":"5","author":"Yano, Y.","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.suppl_1.31"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.1047-1050.2004"},{"key":"atypb11","first-page":"53","volume":"5","author":"Bartner, E.","year":"1958","journal-title":"Antibiot Annu"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00944.x"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.2473063.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1086\/317451"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1086\/341401"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1086\/514672"},{"key":"atypb17","unstructured":"Casarett, LJ , Doull, J. Casarett and Doull\u2019s toxicology: the basic science of poisons. 7th ed. McGraw-Hill Companies, Inc, NY, USA; 2008. p. 583-608."},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9154"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.4.1013"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.5.1116"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.143"},{"key":"atypb22","unstructured":"Ragan, HA, Weller, RE Markers on renal function and injury. In: Walter, FL, Fred, WQ, (eds), The Clinical chemistry of laboratory animals. Taylor & Francis, Philadelphia and Pennsylvania , USA; 1999. p. 519-548."},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1177\/14.9.658"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327109105404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327109105404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:45:07Z","timestamp":1777448707000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327109105404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1177\/0960327109105404"],"URL":"https:\/\/doi.org\/10.1177\/0960327109105404","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}