{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:18:57Z","timestamp":1778721537389,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>Chloroform is a potent central nervous system and respiratory depressant. The toxicities associated with chloroform frequently occur after inhalation. Hepatotoxicity is secondary to production of a toxic metabolite, with a peak elevation of liver enzymes 72 hours after exposure. Acute liver failure after chloroform inhalation is rarely described, this syndrome being produced mainly by viral hepatitis, idiosyncratic drug-induced liver injury, and acetaminophen ingestion. This report describes the case of a 46-year-old woman who presented to emergency department with coma, signs of respiratory failure, and solvent odor of her breath after chloroform inhalation and binge drinking. In evolution appeared lethal acute liver failure and rhabdomyolysis, despite maximum supportive care. Necroptic examination revealed microvesicular steatosis and tubular renal necrosis, specific for chloroform toxicity. This case illustrates the dramatic impact on liver of two well-recognized hepatotoxins. Mechanisms of chloroform and alcohol-induced liver toxicity are reviewed.<\/jats:p>","DOI":"10.1177\/0960327109357142","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T20:33:33Z","timestamp":1262723613000},"page":"615-622","source":"Crossref","is-referenced-by-count":22,"title":["Lethal complications after poisoning with chloroform \u2014 case report and literature review"],"prefix":"10.1177","volume":"29","author":[{"given":"C\u0103t\u0103lina","family":"Lionte","sequence":"first","affiliation":[{"name":"Medical Clinic, \u201c Sf.Ioan\u201d Emergency Clinic Hospital, \u201c Gr.T.Popa\u201d University of Medicine and Pharmacy, Iasi, Romania,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.3.266"},{"key":"atypb2","first-page":"144","volume":"22","author":"Wawersik J.","year":"1997","journal-title":"Anaesthesiol Reanim"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/70.3.339"},{"key":"atypb4","volume-title":"Diseases of the liver and billiary system","author":"Sherlock S.","year":"1993","edition":"9"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1086\/381446"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052270"},{"key":"atypb7","volume-title":"Rhabdomyolysis","author":"Farmer J.","year":"1997","edition":"2"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10053"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198205000-00002"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.4037\/ccn2003.23.6.14"},{"key":"atypb11","volume-title":"Pesticides","author":"Schenker MB","year":"2007","edition":"4"},{"key":"atypb12","unstructured":"Deshon HD Chloroform. In: Grayson M, Eckroth D (ed) Kirk-Othmer Encyclopedia of Chemical Technology, Vol. 5. 3rd ed. New York: John Wiley & Sons, 1979."},{"key":"atypb13","volume":"2","author":"Clayton GD","year":"1981","journal-title":"Toxicology"},{"key":"atypb14","volume-title":"The halogenated hydrocarbons","author":"Meredith TJ","year":"1983"},{"key":"atypb15","volume":"2","author":"Torkelson TR","year":"1981","journal-title":"Patty\u2019s Industrial Hygiene and Toxicology"},{"key":"atypb16","volume-title":"Hydrocarbons and volatile substances","author":"Wax PM","year":"2004","edition":"6"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197412000-00005"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(80)90356-1"},{"key":"atypb19","first-page":"276","volume":"7","author":"Patrick L.","year":"2002","journal-title":"Treatment approaches using vitamin E, magnesium, and betaine. Altern Med Rev"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.40.1.43"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1973.03220290048012"},{"key":"atypb22","volume-title":"The merck index. An encyclopedia of chemicals, drugs, and biologicals","author":"Windholz M.","year":"1983","edition":"10"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.3109\/01480547809105020"},{"key":"atypb24","volume-title":"Chloroform, a study after 100 Years","author":"Waters RM","year":"1951"},{"key":"atypb25","unstructured":"Wexler P., Anderson BD, de Peyster A., Gad SC, Hakkinen PJ, Kamrin MA, Locey BJ, Mehendale HM, Pope CN, Shugart LR Encyclopedia of toxicology, 2nd ed. Vol. 1. San Diego: Elsevier Academic Press, 2005."},{"key":"atypb26","first-page":"21","volume":"201","author":"Meichsner K.","year":"1998","journal-title":"Archiv fur Kriminologie"},{"key":"atypb27","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1520\/JFS13951J","volume":"41","author":"Kim N.","year":"1996","journal-title":"J Forensic Sci"},{"key":"atypb28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00369015","volume":"24","author":"Bomski H.","year":"1967","journal-title":"Gewerbehyg"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199902)35:2<132::AID-AJIM4>3.0.CO;2-I"},{"key":"atypb30","first-page":"821","volume":"2","author":"Palmer AK","year":"1979","journal-title":"J Environ Path Toxicol"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(79)90406-X"},{"key":"atypb32","first-page":"1073","volume":"26","author":"Kim H.","year":"2008","journal-title":"Am J Emerg Med"},{"key":"atypb33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1164-6756(99)80121-2","volume":"8","author":"Thouret JM","year":"1999","journal-title":"Reanimation Urgences"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/79.3.402"},{"key":"atypb35","first-page":"319","volume":"51","author":"Harada K.","year":"1997","journal-title":"Nihon Hoigaku Zasshi"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(94)90051-5"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/17.2.99"},{"key":"atypb38","first-page":"132","volume":"52","author":"Ger J.","year":"1993","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"atypb39","first-page":"39","volume":"38","author":"Sarkar M.","year":"1990","journal-title":"Indian Journal of Anaesthesia"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90421-8"},{"key":"atypb41","first-page":"31","volume":"30","author":"Phoon WH","year":"1983","journal-title":"Med J Malaysia"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198101000-00001"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1539\/joh.44.193"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.76.895.280"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/37.12.972"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2005.027466"},{"key":"atypb47","first-page":"799","volume":"2","author":"Roe FJC","year":"1979","journal-title":"J Environ Toxicol"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1080\/0002889768507551"},{"key":"atypb49","first-page":"442","volume":"73","author":"Wallace CJ","year":"1950","journal-title":"Calif. Med."},{"key":"atypb50","volume-title":"Hydrocarbons","author":"Hernandez B.","year":"2006"},{"key":"atypb51","volume-title":"Toxicology in adults","author":"Corbridge T.","year":"2005","edition":"3"},{"key":"atypb52","volume-title":"N-Acetylcysteine","author":"Howland MA","year":"2006","edition":"8"},{"key":"atypb53","volume-title":"Carbon tetrachloride and chloroform","author":"Fung F.","year":"2007","edition":"5"},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.1186\/cc2978"},{"key":"atypb55","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1988.00380070059015"},{"key":"atypb56","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000130761.78627.10"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327109357142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327109357142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:45:36Z","timestamp":1777448736000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327109357142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,5]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1177\/0960327109357142"],"URL":"https:\/\/doi.org\/10.1177\/0960327109357142","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,5]]}}}