{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:25:00Z","timestamp":1777667100880,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>Anti-ulcerogenic activity of Thamira parpam (TP) was investigated in two ulcer models (aspirin + pylorus ligation and HCl-ethanol). Aspirin\u2014pylorus ligation (Asp 200 mg\/kg-7 days + PL-4 hours) and HCl-ethanol (150 mM HCl in 70% ethanol) induction in rat resulted in elevation of thiobarbituric acid reactive substances (TBARS) and depletion of antioxidants (superoxide dismutase [SOD], glutathione [GSH], glutathione peroxidase [GPx]) with high ulcer scores (p &lt; .01). In Asp + PL model, TP treatment showed mild inhibition on ulcer scores, changes in pH, gastric volume, total and free acidity, and elevation of TBARS and depletion of antioxidants. Compared to the ulcer-untreated rats (HCl-ethanol), the herbomineral drug TP treatment (0.5, 1, 2 mg\/kg, per oral [p.o.]) attenuated the elevation of TBARS, decrease of antioxidants and nitrite (p &lt; .05). Histopathological examinations were correlated with the antioxidant profile. In conclusion, the prophylactic cytoprotective nature of the herbomineral drug in experimentally induced ulcers could be mediated by its free radical quenching property.<\/jats:p>","DOI":"10.1177\/0960327109357217","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T20:33:33Z","timestamp":1262723613000},"page":"161-173","source":"Crossref","is-referenced-by-count":6,"title":["Anti-ulcer role of herbomineral siddha drug \u2014 Thamira parpam on experimentally induced gastric mucosal damage in rats"],"prefix":"10.1177","volume":"29","author":[{"given":"M.","family":"Vasanthkumar","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Herbal and Indian Medicine Research Laboratory, Sri Ramachandra University, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RP","family":"Parameswari","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Herbal and Indian Medicine Research Laboratory, Sri Ramachandra University, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Vijaya Kumar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Herbal and Indian Medicine Research Laboratory, Sri Ramachandra University, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MK","family":"Sangeetha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Herbal and Indian Medicine Research Laboratory, Sri Ramachandra University, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Gayathri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Herbal and Indian Medicine Research Laboratory, Sri Ramachandra University, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Balaji Raghavendran","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Herbal and Indian Medicine Research Laboratory, Sri Ramachandra University, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Chamundeeswari","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Sri Ramachandra University, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah R","family":"Vasanthi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Herbal and Indian Medicine Research Laboratory, Sri Ramachandra University, Chennai, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"atypb1","first-page":"361","volume":"95","author":"Konturek PC","year":"2001","journal-title":"J Physiol"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/026921639500900402"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-003-0479-y"},{"key":"atypb4","first-page":"315","volume":"4","author":"Dhikav V.","year":"2003","journal-title":"J Indian Clin Med"},{"key":"atypb5","unstructured":"Thiagarajan R. 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