{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:26:00Z","timestamp":1777667160816,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T00:00:00Z","timestamp":1262736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>The aim of this study was to investigate, through the single-cell gel (comet) assay, whether vitamin C is able to protect against renovascular hypertension-induced genotoxicity in multiple organs. A total of 32 male Wistar rats were divided into four groups: negative control (n = 6); animals treated with vitamin C (n = 6); hypertensive rats (n = 10) and hypertensive rats and treated with vitamin C (n = 10). Hypertension was induced as a result of partial obstruction of the left renal artery by means of a silver clip during 6 weeks. Vitamin C was administered at 150 mg\/kg during 7 consecutive days before the end of the experimental period. The results showed that vitamin C was able to protect blood cells against hypertension-induced genotoxicity. Brain, liver and heart cells were also protected by vitamin C following hypertension-induced genotoxic damage. Regarding blood pressure, vitamin C reduced the hypertensive state. In conclusion, our results suggest that vitamin C can prevent hypertension-induced DNA damage in blood, liver, brain and heart cells as well as to normalize the blood pressure of rats.<\/jats:p>","DOI":"10.1177\/0960327109358267","type":"journal-article","created":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T20:41:45Z","timestamp":1262810505000},"page":"593-599","source":"Crossref","is-referenced-by-count":22,"title":["Vitamin C prevents DNA damage induced by renovascular hypertension in multiple organs of Wistar rats"],"prefix":"10.1177","volume":"29","author":[{"given":"Erika Emy","family":"Nishi","sequence":"first","affiliation":[{"name":"Department of Physiology, Cardiovascular Division, Paulista Medical School, Federal University of Sao Paulo, UNIFESP, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruy","family":"Ribeiro Campos","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Division, Paulista Medical School, Federal University of Sao Paulo, UNIFESP, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassia","family":"Toledo Bergamaschi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Division, Paulista Medical School, Federal University of Sao Paulo, UNIFESP, SP, Brazil, Department of Biosciences, Federal University of Sao Paulo, UNIFESP, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor","family":"Rossi de Almeida","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Federal University of Sao Paulo, UNIFESP, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Araki Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Federal University of Sao Paulo, UNIFESP, SP, Brazil,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,1,6]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2007.11.004"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2006.12.008"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-139X.2003.16033.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.08.072"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2007.12"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.17"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311370200"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)80347-6"},{"key":"atypb9","first-page":"851","volume":"21","author":"Demirbag R.","year":"2005","journal-title":"Can J Cardiol"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816030-00006"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.10.024"},{"key":"atypb12","first-page":"177","volume":"43","author":"Walker AF","year":"1996","journal-title":"Biologist"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S8755-9668(86)80021-7"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(88)90265-0"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-008-9187-9"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1177\/0960327107076288"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2006.12.007"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.11.004"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.6.1117"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1159\/000222245"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(02)00128-6"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2006.09.001"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.02.014"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/18.1.45"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.49.301"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1081\/CEH-200067681"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2006.00275.x"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D224"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2007.01.003"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-009-9218-1"}],"container-title":["Human &amp; 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