{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:24:33Z","timestamp":1777667073793,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T00:00:00Z","timestamp":1269907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>Sodium fluoroacetate (SFAC) is a potent rodenticide, largely used for rodent and domestic pest control. The toxic effects of SFAC are caused by fluoroacetate, a toxic metabolite, whose toxic action blocks the Krebs cycle and also induces the accumulation of citrate in the body, which is a serum calcium chelator. The most common clinical signs of this intoxication are the cardiac and neurological effects. However, the hematological, biochemical and histopathological findings occurring in intoxication are still unknown in different species. In the present study, 16 domestic cats were experimentally intoxicated with oral doses of fluoroacetate (0.45 mg\/kg). The hematological and biochemical profiles and histopathological findings were made to look for auxiliary diagnosis methods in SFAC intoxications. The hematological profile showed transitory leucopenia and thrombocytopenia; in the biochemical profiles were detected hyperglycemia, increase of creatinequinase enzyme (CK) and creatinequinase cardiac isoenzyme (CK-MB), hypokalemia and hypophosfatemia. In the macroscopic and histopathological findings were observed lesions characteristic of degenerative and ischemic processes in heart, kidneys, liver, brain and lungs. These changes may be auxiliary to the diagnosis of intoxication by SFAC in cats, when associated with clinical signs described for the species. Thus, the complete blood count with platelet count, serum glucose, enzymes CK and CK-MB isoenzyme, as well as the electrolytes potassium and phosphorus, can facilitate the laboratory diagnosis during intoxication by SFAC, associated with the pathological findings in the case of death of the intoxicated animal.<\/jats:p>","DOI":"10.1177\/0960327110362908","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T20:35:53Z","timestamp":1269981353000},"page":"903-913","source":"Crossref","is-referenced-by-count":9,"title":["Hematological and biochemical profiles and histopathological evaluation of experimental intoxication by sodium fluoroacetate in cats"],"prefix":"10.1177","volume":"29","author":[{"given":"RC","family":"Collicchio-Zuanaze","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinic, Faculty of Veterinary Medicine and Animal Science of the S\u00e3o Paulo State University, Unesp, Botucatu, Brazil,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sakate","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinic, Faculty of Veterinary Medicine and Animal Science of the S\u00e3o Paulo State University, Unesp, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Langrafe","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinic, Faculty of Veterinary Medicine and Animal Science of the S\u00e3o Paulo State University, Unesp, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RK","family":"Takahira","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinic, Faculty of Veterinary Medicine and Animal Science of the S\u00e3o Paulo State University, Unesp, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Burini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinic, Faculty of Veterinary Medicine and Animal Science of the S\u00e3o Paulo State University, Unesp, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,3,30]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1080\/00219266.1986.9654836"},{"key":"atypb2","first-page":"59","volume":"110","author":"Palermo-Neto J.","year":"1995","journal-title":"Folha Medica"},{"key":"atypb3","first-page":"427","volume":"32","author":"Omara F.","year":"1990","journal-title":"Vet Hum Toxicol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1191\/0960327106ht609oa"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1042\/bj0640161"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1071\/WR9810369"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90904-5"},{"key":"atypb8","volume-title":"Veterinary toxicology","author":"Humphrejs DJ","year":"1988"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-124-31732"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(81)90523-2"},{"key":"atypb11","volume-title":"Manual of histological staining methds of armed forces Institute of Pathology","author":"Luna LG","year":"1968"},{"key":"atypb12","volume-title":"Biostatical analysis","author":"Zar JH","year":"1996"},{"key":"atypb13","volume-title":"Clinical biochemistry of domestic animals","author":"Kaneko JJ","year":"1997"},{"key":"atypb14","volume-title":"Exames laboratoriais em medicina veterin\u00e1ria - bioqu\u00edmica cl\u00ednica e hematologia","author":"Kerr MG","year":"2003"},{"key":"atypb15","volume-title":"Guia de Hematologia para C\u00e3es e Gatos","author":"Rebar AH","year":"2003"},{"key":"atypb16","volume-title":"Hematology and oncology: leukopenia e lymphocytopenia and disorders of the spleen","author":"Beers MH","year":"1999"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0914a"},{"key":"atypb18","first-page":"129","volume":"16","author":"Vac\u00e9k A.","year":"1970","journal-title":"Folia Biologica"},{"key":"atypb19","first-page":"707","volume":"34","author":"Chi C.","year":"1996","journal-title":"Clin Toxicol"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1191\/096032799678840200"},{"key":"atypb21","volume-title":"Small animal clinical diagnosis by laboratory methods","author":"Willard MD","year":"1994"},{"key":"atypb22","volume-title":"Patologia Estrutural e Funcional","author":"Cotran R.","year":"2000"},{"key":"atypb23","volume-title":"F\u00edgado e p\u00e2ncreas ex\u00f3crino","author":"Dimsk DF","year":"1999"},{"key":"atypb24","volume-title":"Farmacologia aplicada \u00e0 medicina veterin\u00e1ria","author":"Spinosa HS","year":"1999"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1007\/BF01839386"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00083-2"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1980.tb02030.x"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(87)90180-3"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69083-9_40"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1038\/2091197a0"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-198102000-00015"},{"key":"atypb32","first-page":"237","volume":"49","author":"Schultz RA","year":"1982","journal-title":"Onderstepoort J Vet Res"},{"key":"atypb33","first-page":"1","volume":"10","author":"Tokarnia CH","year":"1990","journal-title":"Pesquisa Veterin\u00e1ria Brasileira"},{"key":"atypb34","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1016\/S0021-9258(18)99562-1","volume":"242","author":"Williamson JR","year":"1967","journal-title":"J Biol Chem"},{"key":"atypb35","first-page":"67","volume":"13","author":"Tokarnia CH","year":"1993","journal-title":"Pesquisa Veterin\u00e1ria Brasileira"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.2131\/jts.29.155"},{"key":"atypb37","first-page":"85","volume":"20","author":"Trabes J.","year":"1983","journal-title":"Clin Toxicol"},{"key":"atypb38","volume-title":"Patologia Veterin\u00e1ria","author":"Jones, TC","year":"2000"},{"key":"atypb39","volume-title":"Diseases of white blood cells, lymph nodes, spleen and thymus","author":"Aster JC","year":"2005"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327110362908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327110362908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:45:20Z","timestamp":1777448720000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327110362908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,30]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1177\/0960327110362908"],"URL":"https:\/\/doi.org\/10.1177\/0960327110362908","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,30]]}}}