{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:29:35Z","timestamp":1777667375494,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T00:00:00Z","timestamp":1267660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>\n                    Hexavalent chromium (CrVI) is a transition element utilized in many fields of modern industries. CrVI is a reproductive metal toxicant that can traverse the placental barrier and cause a wide range of fetal effects. Therefore, the present study was carried out to determine the CrVI-induced utero-toxicity. In the present study, lactating rats received drinking water containing CrVI (50 mg\/L and 200 mg\/L) from postnatal days (PND) 1-21. During PND 1-21, the pups received CrVI via the mother\u2019s milk. Pups from both control and treatment groups were continued on regular diet and water from PND-21 onwards and euthanized on PND-45 and -65. Specific activities antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) were estimated. Hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ), lipid peroxidation (LPO) and serum gonadotropins viz. Luteinizing hormone (LH) and follicle stimulating hormone (FSH) were also assayed. Specific activities of SOD, CAT, GPX, GR and GST and serum testosterone and progesterone were significantly decreased, while H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , LPO and serum FSH was increased in 50\u2014parts per million (ppm) and 200 ppm\u2014treated rats in an age-dependent manner. These results suggest that lactational CrVI exposure induces oxidative stress in rat uterus by decreasing antioxidant enzymes, which were associated with delayed puberty and altered steroids and gonadotrophin levels.\n                  <\/jats:p>","DOI":"10.1177\/0960327110364638","type":"journal-article","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T21:56:50Z","timestamp":1267739810000},"page":"91-101","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Lactational hexavalent chromium exposure-induced oxidative stress in rat uterus is associated with delayed puberty and impaired gonadotropin levels"],"prefix":"10.1177","volume":"30","author":[{"given":"Jawahar B","family":"Samuel","sequence":"first","affiliation":[{"name":"Department of Zoology, St. John's College, Thirunelveli, Tamilnadu, India, Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jone A","family":"Stanley","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dailiah P","family":"Roopha","sequence":"additional","affiliation":[{"name":"Department of Zoology, St. John's College, Thirunelveli, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganapathy","family":"Vengatesh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaganathan","family":"Anbalagan","sequence":"additional","affiliation":[{"name":"Department of 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