{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:26:09Z","timestamp":1777667169234,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T00:00:00Z","timestamp":1274313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>\n                    Male Wistar rats were treated with chokeberry juice per os, 10 mL\/kg\/day, for 28 days and a single intraperitoneal (i.p.) dose of N-nitrosodiethylamine (NDEA), 150 mg\/kg, or carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ), 2 ml\/kg. The level of hepatic microsomal lipid peroxidation, expressed as thiobarbituric acid reactive substances (TBARS), was increased in animals dosed with NDEA and CCl\n                    <jats:sub>4<\/jats:sub>\n                    . Juice pretreatment resulted in a significant decrease in TBARS by 53% and 92%, respectively. In rats administered juice alone, 50% decrease in TBARS was noted. The activities of all antioxidant enzymes were decreased in the liver of rats administered either toxicant by 29%\u201452% as compared to controls. Juice pretreatment resulted in an increase in the activity of catalase, glutathione peroxidase and glutathione reductase by 117%, 56% and 44%, respectively, only in rats challenged with NDEA. Although no response of plasma protein carbonyls to both toxicants was observed, the pretreatment with juice caused a 55% decrease of this parameter in CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2014dosed rats. DNA damage in blood leukocytes induced by either toxicant was slightly reduced, by 24%, in the rats pretreated with juice and administered NDEA. The results of the study showed that pretreatment with chokeberry juice confers some protection against chemical-induced oxidative stress.\n                  <\/jats:p>","DOI":"10.1177\/0960327110371697","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T20:34:28Z","timestamp":1274387668000},"page":"199-208","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Protective effect of chokeberry on chemical-induced oxidative stress in rat"],"prefix":"10.1177","volume":"30","author":[{"given":"Ma\u0142gorzata","family":"Kujawska","sequence":"first","affiliation":[{"name":"Department of Toxicology, Pozna\u0144 University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Ignatowicz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biochemistry, Pozna\u0144 University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Ewertowska","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Pozna\u0144 University of Medical Sciences, Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Oszmia\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Fruit, Vegetable and Cereal Technology, Environmental and Life Science University, Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Jodynis-Liebert","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Pozna\u0144 University of Medical Sciences, Pozna\u0144, Poland,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,5,20]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1088306"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-005-0002-5"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/s003940050065"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1021\/jf020728u"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1155\/S1110724304404045"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1021\/jf049517a"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1021\/jf030479p"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2006.05.003"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1080\/09537100701708506"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00626.2005"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1159\/000191290"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1207\/s15327914nc5401_10"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0715"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1021\/jf034818q"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2005.01.001"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2004.04.012"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2007.29.2.1075349"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-008-0087-7"},{"key":"atypb19","unstructured":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans . 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