{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:26:18Z","timestamp":1777667178859,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T00:00:00Z","timestamp":1274313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>Background: Tricyclic antidepressant (TCA) intoxication contributes a large number of drug toxicities with serious complications. There are a few studies about factors associated with TCA intoxication. This study therefore aimed to identify determinants of this type of intoxication. Methods: A cross-sectional study was carried out at Loghman-Hakim Poison Hospital during a 6-month period. All poisoned patients aged &gt;12 years presented to this hospital during the mentioned period were evaluated. Then, TCA-poisoned patients were compared with other drug intoxications as the control group to determine factors associated with TCA intoxications. Results: There were 9809 admissions, of which 1583 (16.1%) patients including 601 (38%) males were intoxicated with TCAs. Mean age of the subjects was 26.5 + 10 years. Most of the TCA intoxications (74.4%) were intentional (p = 0.01). Amitriptyline was the most frequent agent followed by Nortriptyline. There was no significant difference between TCA and non-TCA intoxications regarding the mortality (1.3% in TCA vs. 1.1% in others, p = 0.45). Logistic regression analysis revealed that sex, addiction status, and history of psychological problems have association with TCA intoxication. Conclusions: The results of this study are helpful in identifying individuals who are prone to TCA intoxication and may be useful in implementation of preventive strategies.<\/jats:p>","DOI":"10.1177\/0960327110371701","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T20:34:28Z","timestamp":1274387668000},"page":"283-288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Tricyclic antidepressants intoxication in Tehran, Iran: Epidemiology and associated factors"],"prefix":"10.1177","volume":"30","author":[{"given":"Saied","family":"Dianat","sequence":"first","affiliation":[{"name":"Sina Trauma and Surgery Research Center, Sina Hospital, Tehrarn University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammd-Reza","family":"Zarei","sequence":"additional","affiliation":[{"name":"Sina Trauma and Surgery Research Center, Sina Hospital, Tehrarn University of Medical Sciences, Tehran, Iran, Department of Emergency Medicine, Imam Khomeini hospital, Tehrarn University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Hassanian-Moghaddam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Clinical Toxicology, Loghman-Hakim Poison Hospital, Shahid Beheshti University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Rashidi-Ranjbar","sequence":"additional","affiliation":[{"name":"Sina Trauma and Surgery Research Center, Sina Hospital, Tehrarn University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Rahimian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad R","family":"Rasouli","sequence":"additional","affiliation":[{"name":"Sina Trauma and Surgery Research Center, Sina Hospital, Tehrarn University of Medical Sciences, Tehran, Iran,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,5,20]]},"reference":[{"key":"atypb1","volume-title":"Textbook of Forensic Medicine and Toxicology","author":"Pillay VV","year":"2004","edition":"14"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1191\/0960327104ht460oa"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.183.1.34"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2004.06.001"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2005.05.001"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.2165\/00139709-200524030-00010"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1136\/emj.18.4.236"},{"key":"atypb8","first-page":"153","volume":"46","author":"Haddad LM","year":"1992","journal-title":"Am Fam Physician"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02553.x"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/BF02914492"},{"key":"atypb11","unstructured":"Linden CH, Burns MJ Poisoning and drug overdosage. 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