{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:27:01Z","timestamp":1777667221842,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T00:00:00Z","timestamp":1280361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-year-old male patient who took 14.5 g of mesalazine rectally and orally for suicide purpose is discussed. He was an ulcerative colitis patient and depressed about his illness and routine life traffic. Although it was hard for him to take the suppository form orally because of its bad taste and structure, he took it with the help of water. In the patient\u2019s colonoscopy, diffuse hyperemia and edema extending from the anal channel to the proximal rectal mucosa and a 1.5 cm diameter ulcer expanding from anal channel through the rectum were identified. No pathology was found in the upper gastrointestinal endoscopy. Routine laboratory examination was performed and no abnormality was identified in the patient\u2019s total blood account, biochemical parameters and full-urine examination. In the control rectoscopy applied to the patient 15 days later, recovery of the ulcer was observed and he was discharged to be followed in the psychiatry clinic.<\/jats:p>","DOI":"10.1177\/0960327110379249","type":"journal-article","created":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T20:41:13Z","timestamp":1280436073000},"page":"772-776","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["An unusual case of mesalazine intoxication: Oral and rectal overloading of                 the rectal suppository form"],"prefix":"10.1177","volume":"30","author":[{"given":"Zikret","family":"Koseoglu","sequence":"first","affiliation":[{"name":"Department of Emergency, Adana Numune Research and Education Hospital,                         Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim","family":"Satar","sequence":"additional","affiliation":[{"name":"Department of Emergency, Adana Numune Research and Education Hospital,                         Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Adana Numune Research and Education                         Hospital, Adana, Turkey,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Sebe","sequence":"additional","affiliation":[{"name":"Department of Emergengy, Faculty of Medicine, Cukurova University, Adana,                         Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozgun","family":"Kosenli","sequence":"additional","affiliation":[{"name":"Department of Emergency, Adana Numune Research and Education Hospital,                         Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,7,29]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000212654.28527.d0"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0269-2813.2004.01827.x"},{"key":"atypb3","first-page":"893","volume":"3","author":"Karagozian R.","year":"2007","journal-title":"Ther Clin Risk Manag"},{"key":"atypb4","first-page":"126","volume":"10","author":"Tursi A.","year":"2004","journal-title":"Med Sci Monit"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.53.1.155"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02152.x"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.3109\/15563659109025753"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070442"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70182-4"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.07.026"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.37.26448"},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-2036.2004.02048.x","volume":"20","author":"Hanauer SB","year":"2004","journal-title":"Aliments Pharmacol Ther"},{"key":"atypb13","first-page":"487","volume":"83","author":"Bachrach WH","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197309062891001"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03058.x"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03069.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198600321-00003"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70627-4"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0428-2"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20135"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236902"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296159"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.6.783"},{"key":"atypb24","first-page":"562","volume":"85","author":"Zinberg J.","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"atypb25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0889-8553(21)00421-0","volume":"18","author":"Das KM","year":"1989","journal-title":"Gastroenterol Clin N Am"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6520.599"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1995.tb00384.x"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198938040-00003"}],"container-title":["Human &amp; 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