{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:28:12Z","timestamp":1777667292162,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T00:00:00Z","timestamp":1292803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>\n                    The toxicity of Nanjing drinking water on mouse (Mus musculus) was detected by\n                    <jats:sup>1<\/jats:sup>\n                    H nuclear magnetic resonance (NMR)-based metabonomic method. Three groups of mice were fed with drinking water (produced by Nanjing BHK Water Plant), 3.8 \u03bcg\/L benzo(a)pyrene as contrast, and clean water as control, respectively, for 90 days. It was observed that the levels of lactate, alanine, and creatinine in the mice fed with drinking water were increased and that of valine was decreased. The mice of drinking water group were successfully separated from control. The total concentrations of polycyclic aromatic hydrocarbons (PAHs), phthalates (PAEs), and other organic pollutants in the drinking water were 0.23 \u03bcg\/L, 4.57 \u03bcg\/L, and 0.34 \u03bcg\/L, respectively. In this study, Nanjing drinking water was found to induce distinct perturbations of metabolic profiles on mouse including disorders of glucose-alanine cycle, branched-chain amino acid and energy metabolism, and dysfunction of kidney. This study suggests that metabonomic method is feasible and sensitive to evaluate potential toxic effects of drinking water.\n                  <\/jats:p>","DOI":"10.1177\/0960327110386817","type":"journal-article","created":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T00:18:25Z","timestamp":1292890705000},"page":"1088-1095","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Metabolic profiles in serum of mouse after chronic exposure to drinking water"],"prefix":"10.1177","volume":"30","author":[{"family":"Yan Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjng, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Bing Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjng, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Xuxiang Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjng, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Aimin Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjng, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Shupei Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjng, PR China,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,12,20]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-008-2481-2"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1021\/es801845a"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22656"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1021\/es901602d"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.07.066"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1080\/004982599238047"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1038\/nrd728"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnmrs.2008.11.004"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1021\/pr0601584"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1021\/pr9000256"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1021\/pr0703021"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2007.02.020"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.11.010"},{"key":"atypb14","author":"EMC","year":"2006","journal-title":"Environmental Monitoring of China"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-008-0113-7"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.376"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.55.52"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1301\/nr.2004.jan.33-38"},{"key":"atypb19","first-page":"19","volume":"26","author":"Wilcox G.","year":"2005","journal-title":"Clin Biochem Rev"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.698"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2007.07.010"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.07.013"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.90"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1441"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/S1002-0160(07)60045-9"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327110386817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327110386817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:46:06Z","timestamp":1777448766000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327110386817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,20]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1177\/0960327110386817"],"URL":"https:\/\/doi.org\/10.1177\/0960327110386817","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,20]]}}}