{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:28:16Z","timestamp":1777667296412,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T00:00:00Z","timestamp":1287964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>\n                    The clinical course of losartan potassium\/hydrochlorothiazide (Preminent\n                    <jats:sup>\u00ae<\/jats:sup>\n                    )-induced hyponatremia has not been described. We summarized 40 patients with Preminent-induced hyponatremia. The study involved 15 (37.5%) men and 25 (62.5%) women (mean age [SD], 76.4 [8.3] years; range, 55\u201395). Their sodium levels before Preminent administration were 139.5 (4.9) mEq\/L (range, 131\u2013145; reference range, 135\u2013147). The duration from the day of Preminent administration to the day with the lowest sodium level was 59.3 (64.9) days (range, 2\u2013207; median, 24). Most patients for whom this duration was &lt;50 days exhibited progressive symptoms, whereas most of those for whom this duration was &gt;50 days did not exhibit progressive symptoms but exhibited symptoms after fever or appetite loss. The lowest sodium value was 114.4 (8.2) mEq\/L (range, 99\u2013133). The duration from the time of Preminent discontinuation to (1) the time of early recovery and (2) the time of final recovery was 6.8 (5.5) days (range, 1\u201320; median, 5) and 11.6 (7.6) days (range, 2\u201329; median, 7.5), respectively. Of the 40 patients, 36 (90.0%) achieved full recovery, 1 (2.5%) suffered from after-effects due to central pontine myelinolysis, 1 (2.5%) died, and 2 (5.0%) were unknown. In the analysis of other adverse effects of Preminent and the same adverse effects of other three angiotensin II receptor blocker (ARB)\/thiazide combinations, hyponatremia was observed as a primary adverse effect of all ARB\/thiazide combinations. However, hyperesthesia dermatitis was reported as an adverse effect of Preminent only.\n                  <\/jats:p>","DOI":"10.1177\/0960327110387455","type":"journal-article","created":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T22:08:35Z","timestamp":1288044515000},"page":"1409-1414","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Losartan potassium\/hydrochlorothiazide (Preminent\n                    <sup>\u00ae<\/sup>\n                    ) and hyponatremia: Case series of 40 patients"],"prefix":"10.1177","volume":"30","author":[{"given":"Hiroyuki","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Touru","family":"Yaguramaki","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsuko","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Fujiki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Tomiyama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobunori","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiatsu","family":"Yakushiji","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,10,25]]},"reference":[{"key":"bibr1-0960327110387455","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X132514"},{"key":"bibr2-0960327110387455","unstructured":"Pharmaceuticals and Medical Devices Agency (PMDA). http:\/\/www.pmda.go.jp (accessed July 7, 2010)."},{"key":"bibr3-0960327110387455","unstructured":"Reports on the adverse effects of drugs on PMDA database. http:\/\/www.info.pmda.go.jp\/fsearchnew\/jsp\/menu_fukusayou_base.jsp (accessed July 7, 2010)."},{"key":"bibr4-0960327110387455","unstructured":"Reports on the adverse effects of losartan\/hydrochlorothiazide (Preminent) on PMDA database. http:\/\/www.info.pmda.go.jp\/fsearchnew\/fukusayouMainServlet?scrid=SCR_LIST&evt=SHOREI&type=1&pID=2149110&name=%A5%D2%A5%C9%A5%ED%A5%AF%A5%ED%A5%ED&fuku=&root=1&srtnendo=2&page_max=100&page_no=0 (accessed July 7, 2010)."},{"key":"bibr5-0960327110387455","unstructured":"Reports on the adverse effects of valsartan\/hydrochlorothiazide (Co-Dio) on PMDA database. http:\/\/www.info.pmda.go.jp\/fsearchnew\/fukusayouMainServlet?scrid=SCR_LIST&evt=COUNT&pID=2149112&name=%A5%B3%A5%C7%A5%A3%A5%AA&fuku=&root=1&srtnendo=2&nendo=0 (accessed July 7, 2010)."},{"key":"bibr6-0960327110387455","unstructured":"Reports on the adverse effects of candesartan\/hydrochlorothiazide (Ecard) on PMDA database. http:\/\/www.info.pmda.go.jp\/fsearchnew\/fukusayouMainServlet?scrid=SCR_LIST&evt=COUNT&pID=2149111&name=%A5%A8%A5%AB%A1%BC%A5%C9&fuku=&root=1&srtnendo=2&nendo=0 (accessed July 7, 2010)."},{"key":"bibr7-0960327110387455","unstructured":"Reports on the adverse effects of telmisartan\/hydrochlorothiazide (Micombi) on PMDA database. http:\/\/www.info.pmda.go.jp\/fsearchnew\/fukusayouMainServlet?scrid=SCR_LIST&evt=COUNT&pID=2149113&name=%A5%DF%A5%B3%A5%F3%A5%D3&fuku=&root=1&srtnendo=2&nendo=0 (accessed July 7, 2010)."},{"key":"bibr8-0960327110387455","unstructured":"Anthony F, Eugene B, Dennis K, Stephen H, Dan L, Jameson J, Harrison\u2019s principles of internal medicine. 17th ed. USA: McGraw-Hill Companies Inc, 2008, p.278."},{"key":"bibr9-0960327110387455","doi-asserted-by":"publisher","DOI":"10.1159\/000045413"},{"key":"bibr10-0960327110387455","unstructured":"Anthony F, Eugene B, Dennis K, Stephen H, Dan L, Jameson J, Harrison\u2019s principles of internal medicine. 17th ed. USA: McGraw-Hill Companies Inc, 2008, p.1559."},{"key":"bibr11-0960327110387455","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-1-24"},{"key":"bibr12-0960327110387455","unstructured":"Reports on the adverse effects of hydrochlorothiazide (Dichlotride) on PMDA database. http:\/\/www.info.pmda.go.jp\/fsearchnew\/fukusayouMainServlet?scrid=SCR_LIST&evt=SHOREI&type=1&pID=2132004&name=%A5%D2%A5%C9%A5%ED%A5%AF%A5%ED%A5%ED&fuku=&root=1&srtnendo=2&page_max=100&page_no=0 (accessed July 7, 2010)."},{"key":"bibr13-0960327110387455","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001458"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327110387455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327110387455","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327110387455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:46:07Z","timestamp":1777448767000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327110387455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,25]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1177\/0960327110387455"],"URL":"https:\/\/doi.org\/10.1177\/0960327110387455","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,25]]}}}