{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:28:48Z","timestamp":1777667328951,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T00:00:00Z","timestamp":1291680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>\n                    Carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) is a common hepatotoxin used in experimental models to elicit liver injury. To identify the proteins involved in CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced hepatotoxicity, two-dimensional gel electrophoresis was employed followed by mass spectrometry - mass spectrometry (MS\/MS) to study the differentially expressed proteins during CCl\n                    <jats:sub>4<\/jats:sub>\n                    exposure in the Fischer 344 rat liver proteome for 5 weeks. Ten spots with notable changes between the Control and CCl\n                    <jats:sub>4<\/jats:sub>\n                    groups were successfully identified. Among them, four proteins with significant up-regulation, namely calcium-binding protein 1, protein disulfide isomerase, mitochondrial aldehyde dehydrogenase precursor, and, glutathione-S-transferase mu1 and six proteins with significant down-regulation, namely catechol- O-methyltransferase, hemoglobin-alpha-2-chain, hemopexin precursor, methionine sulfoxide reductase A, catalase and carbonic anhydrase 3, were identified. The data indicates that CCl\n                    <jats:sub>4<\/jats:sub>\n                    causes hepatotoxicity by depleting oxygen radical scavengers in the hepatocytes. In this rat model, we profiled hepatic proteome alterations in response to CCl\n                    <jats:sub>4<\/jats:sub>\n                    intoxication. The findings should facilitate understanding of the mechanism of CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced liver injury.\n                  <\/jats:p>","DOI":"10.1177\/0960327110391388","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T20:49:18Z","timestamp":1291754958000},"page":"1369-1381","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity"],"prefix":"10.1177","volume":"30","author":[{"given":"Leo Lap Yan","family":"Wong","sequence":"first","affiliation":[{"name":"School of Biological Sciences, The University of Hong Kong, HKSAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheung Tat","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Hong Kong, 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