{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:28:40Z","timestamp":1777667320802,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T00:00:00Z","timestamp":1295395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>Aim: In the study, we examined erdosteine\u2019s effects on platelet functions and coagulation. Materials and methods: A total 29 young albino Wistar rats were divided into four groups. Control rats ( n = 6) were given saline; Group 1 rats ( n = 7) were given 3 mg\/kg erdosteine by oral gavage for 3 days; Group 2 rats ( n = 7) were given 10 mg\/kg erdosteine by oral gavage for 3 days; and Group 3 rats ( n = 9) were given 30 mg\/kg erdosteine for 3 days. Twenty-four hours after the final dose, blood samples were drawn from a portal vein. Prothrombin time (PT), activated partial thromboplastin time (aPTT) and international normalized ratio (INR) were measured, and platelet counts were examined in a peripheral blood smear by light microscopy. Results: PT and INR values of Group 1 increased compared to the controls but did not change in Group 3. Hemostatic parameters were not measured in Group 2 because the blood samples in Group 2\u2019s tubes clotted rapidly. Platelet counts of the peripheral blood from Group 2 were low but were normal in other groups. Conclusion: We have concluded erdosteine may disrupt hemostasis parameters by its different metabolites in patients. Erdosteine has dual effects on hemostasis via its different metabolites, which occur in different doses.<\/jats:p>","DOI":"10.1177\/0960327110396526","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T20:59:31Z","timestamp":1295470771000},"page":"1644-1648","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Dual effects of erdosteine on hemostasis via its different metabolites in young rats"],"prefix":"10.1177","volume":"30","author":[{"given":"Vefik","family":"Arica","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Tutanc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oktay Hasan","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Secil","family":"Arica","sequence":"additional","affiliation":[{"name":"Department of Family Practices, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatmagul","family":"Basarslan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersin Sukru","family":"Erden","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleyman","family":"Oktar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Kaya","sequence":"additional","affiliation":[{"name":"Hematology Division, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,1,19]]},"reference":[{"key":"bibr1-0960327110396526","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199652060-00009"},{"key":"bibr2-0960327110396526","doi-asserted-by":"publisher","DOI":"10.1177\/0748233710369666"},{"issue":"2","key":"bibr3-0960327110396526","first-page":"127","volume":"56","author":"Erden ES","year":"2008","journal-title":"Tuberk Toraks"},{"key":"bibr4-0960327110396526","first-page":"739","volume":"50","author":"Braga PC","year":"2000","journal-title":"Drug Res"},{"key":"bibr5-0960327110396526","first-page":"147","volume":"28","author":"Sasso D","year":"2002","journal-title":"Drugs Exp Clin Res"},{"key":"bibr6-0960327110396526","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043505"},{"key":"bibr7-0960327110396526","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.09.020"},{"key":"bibr8-0960327110396526","doi-asserted-by":"publisher","DOI":"10.3109\/00365519409088566"},{"key":"bibr9-0960327110396526","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/100.2.94"},{"key":"bibr10-0960327110396526","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614361"},{"key":"bibr11-0960327110396526","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200140110-00003"},{"key":"bibr12-0960327110396526","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb02513.x"},{"key":"bibr13-0960327110396526","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-6618(02)00282-7"},{"key":"bibr14-0960327110396526","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-6618(03)00185-3"},{"key":"bibr15-0960327110396526","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.06.004"},{"key":"bibr16-0960327110396526","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199652060-00009"},{"key":"bibr17-0960327110396526","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.1999.03053.x"},{"key":"bibr18-0960327110396526","volume-title":"Sandoz Drug Co","author":"ERDOSTIN\u00ae Prospectus","year":"2009"}],"container-title":["Human &amp; 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