{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:28:49Z","timestamp":1777667329756,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2011,2,7]],"date-time":"2011-02-07T00:00:00Z","timestamp":1297036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>Sulfur dioxide is a typical air pollutant. Sulfite, which is formed at the bronchial mucosa from inhaled sulfur dioxide, might play a role in the exacerbation of asthma. In this study, we investigated the effects of sodium sulfite and its interaction with a house dust mite ( Dermatophagoides pteronyssinus, Der p) on allergic sensitization and airway inflammation. BALB\/c mice were divided into four groups: control ( n = 10), mite intranasal (mIN, n = 12), sodium sulfite intranasal (sIN, n = 12) and mIN + sIN ( n = 12). In non-control groups, the mice were sensitized on day 8 and day 15 with mite allergen subcutaneously. Mite allergen was then administrated intranasally from day 15 to day 22 in mIN and mIN+sIN groups. Sodium sulfite was administrated in sIN and mIN + sIN groups intranasally from day 1 to day 22. Plasma Der p-specific IgE, IgG2a, lung histopathology and cytokine levels (IL-5 and IFN-\u03b3) were analyzed. In comparison between mIN (or sIN) and mIN + sIN group, Der p-specific IgE levels were significantly higher in mIN + sIN group ( p &lt; 0.01). Besides, Der p-specific IgG2a level was significantly lower in mIN + sIN group than mIN (or sIN) group ( p &lt; 0.01). The peribronchiolar, alveolar and total inflammatory scores were increased in the mIN + sIN group comparing with the control group ( p &lt; 0.05, p &lt; 0.01, p &lt; 0.01, respectively). Lung supernatant in mIN + sIN group has higher IL-5\/IFN-\u03b3 ratio than control, mIN or sIN group (all p &lt; 0.05). Our study concluded sodium sulfite may enhance allergic sensitization as well as airway inflammation in mite allergen sensitized BALB\/c mice.<\/jats:p>","DOI":"10.1177\/0960327111398673","type":"journal-article","created":{"date-parts":[[2011,2,7]],"date-time":"2011-02-07T23:54:22Z","timestamp":1297122862000},"page":"1682-1689","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Sodium sulfite aggravated allergic sensitization and airway inflammation in mite allergen sensitized BALB\/c mice"],"prefix":"10.1177","volume":"30","author":[{"given":"Heng-Kuei","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Immunology and Nephrology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaw-Ji","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Chin","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Chin","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Immunology and Nephrology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciao-Jin","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Immunology and Nephrology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Shien","family":"Fu","sequence":"additional","affiliation":[{"name":"Division of Immunology and Nephrology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,2,7]]},"reference":[{"key":"bibr1-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.025"},{"key":"bibr2-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.055"},{"key":"bibr3-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542107"},{"issue":"2","key":"bibr4-0960327111398673","first-page":"63","volume":"22","author":"Nair B","year":"2003","journal-title":"Int J Toxicol"},{"key":"bibr5-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1995.1063"},{"key":"bibr6-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8979163"},{"key":"bibr7-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1002\/em.20142"},{"key":"bibr8-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(77)90020-3"},{"key":"bibr9-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00034305"},{"key":"bibr10-0960327111398673","first-page":"60","volume":"2","author":"Sunyer J","year":"2003","journal-title":"Occup Environ Med"},{"key":"bibr11-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(87)90170-0"},{"key":"bibr12-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90961-X"},{"key":"bibr13-0960327111398673","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1769"},{"key":"bibr14-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb05010.x"},{"key":"bibr15-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01800.x"},{"key":"bibr16-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1080\/00984109708984062"},{"key":"bibr17-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200102000-00007"},{"key":"bibr18-0960327111398673","first-page":"26","volume":"41","author":"Chou CH","year":"2008","journal-title":"J Microbiol Immunol Infect"},{"key":"bibr19-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2007.09.011"},{"key":"bibr20-0960327111398673","first-page":"509","volume":"43","author":"Wang A","year":"2008","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Ze Zhi"},{"key":"bibr21-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/140.6.1828"},{"key":"bibr22-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1016\/0742-8413(96)00012-6"},{"key":"bibr23-0960327111398673","doi-asserted-by":"publisher","DOI":"10.1080\/08958370590922625"}],"container-title":["Human &amp; 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