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The extent of haemolysis was determined spectrophotometrically. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) as indicators of coagulation rate were determined using a coagulatometer. All of the plant extracts tested had a significant effect on coagulation time, prolonging the aPTT. Cassia petersiana had the greatest prolonging effect on PT compared to the control, phosphate buffered saline (PBS). As all of the herbal extracts tested had a delaying effect on coagulation, patients using herbal\/plant therapies should be cautioned to stop their medication before surgery.<\/jats:p>","DOI":"10.1177\/0960327111398675","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T20:47:09Z","timestamp":1296852429000},"page":"250-257","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of selected South African plant extracts on haemolysis and coagulation"],"prefix":"10.1177","volume":"31","author":[{"given":"Werner","family":"Cordier","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan D","family":"Cromarty","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsabie","family":"Botha","sequence":"additional","affiliation":[{"name":"Department of Haematology, National Health Laboratory Services (NHLS), Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Steenkamp","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,2,4]]},"reference":[{"key":"bibr1-0960327111398675","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06911-6.50026-8"},{"key":"bibr2-0960327111398675","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.06.005"},{"key":"bibr3-0960327111398675","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.07.029"},{"key":"bibr4-0960327111398675","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00097-1"},{"key":"bibr5-0960327111398675","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(00)00272-8"},{"key":"bibr6-0960327111398675","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.12.015"},{"key":"bibr7-0960327111398675","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(03)00379-7"},{"key":"bibr8-0960327111398675","doi-asserted-by":"publisher","DOI":"10.1021\/np040106y"},{"key":"bibr9-0960327111398675","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(03)00263-0"},{"key":"bibr10-0960327111398675","first-page":"1888","volume":"86","author":"Pan SF","year":"2006","journal-title":"Effects of Yunnan Baiyao on peri-operative bleeding of patients undergoing cervical open-door laminoplasty: a multi-center randomized double-blind placebo-control trial. 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