{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:28:58Z","timestamp":1777667338350,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2011,2,28]],"date-time":"2011-02-28T00:00:00Z","timestamp":1298851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Naproxen is a non-steroidal anti-inflammatory drug (NSAID) widely used for symptomatic relief of arthritis and other painful disorders, such as dysmenorrheal. Pruritus is the most common side effect of naproxen. Fixed drug eruption (FDE) due to naproxen is a rarely reported side-effect. No previous report has declared cross-reactivity between naproxen and other propionic acid derivatives. A 28-year-old man, presented with edematous and erythematous patchy lesion along with pruritus and inflammation on lip, have been suffering since 3 hours. It started after taking naproxen 550 mg for headache. On detailed inquiry, he defined similar symptom which recurred after whenever he took naproxen. Based on clinical and histopathological findings, it is evaluated as naproxen-induced FDE. We have tested cross-reactivity between naproxen and other propionic acid derivatives, and then we obtained negative result for oral provocation test with flurbiprofen. Here, we present a case of naproxen-induced FDE of 28-year-old man, by overviewing literatures.<\/jats:p>","DOI":"10.1177\/0960327111400105","type":"journal-article","created":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T16:28:17Z","timestamp":1298996897000},"page":"1872-1874","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Naproxen-induced fixed drug eruption: A case report"],"prefix":"10.1177","volume":"30","author":[{"given":"Hikmet","family":"Akyazi","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Medical Faculty, Duzce University, Duzce, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davut","family":"Baltaci","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Fatih District Public Hospital, Trabzon, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevdegul","family":"Mungan","sequence":"additional","affiliation":[{"name":"Pathology Department, Fatih District Public Hospital, Trabzon, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail Hamdi","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Medical Faculty, Duzce University, Duzce, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,2,28]]},"reference":[{"key":"bibr1-0960327111400105","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01405.x"},{"key":"bibr2-0960327111400105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02912.x"},{"key":"bibr3-0960327111400105","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04267.x"},{"issue":"11","key":"bibr4-0960327111400105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5070\/D32Q83T60D","volume":"15","author":"Bandino JP","year":"2009","journal-title":"Dermatol Online J"},{"key":"bibr5-0960327111400105","doi-asserted-by":"publisher","DOI":"10.4065\/75.9.967"},{"issue":"4","key":"bibr6-0960327111400105","first-page":"288","volume":"10","author":"Ozkaya E","year":"2000","journal-title":"Eur J Dermatol"},{"key":"bibr7-0960327111400105","first-page":"134","volume-title":"Andrews\u2019 Diseases of the Skin","author":"Odom RB","year":"2000","edition":"9"},{"key":"bibr8-0960327111400105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1985.tb15266.x"},{"key":"bibr9-0960327111400105","doi-asserted-by":"publisher","DOI":"10.1159\/000249170"},{"key":"bibr10-0960327111400105","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.49886.x"},{"key":"bibr11-0960327111400105","doi-asserted-by":"crossref","unstructured":"Valsecchi R, Cainelli T. Contact dermatitis from ibuproxam. A case with cross-reactivity with ketoprofen.\n                      Contact Dermatitis\n                      1990; 22(1): 51.","DOI":"10.1111\/j.1600-0536.1990.tb01507.x"},{"key":"bibr12-0960327111400105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01537.x"}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327111400105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327111400105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327111400105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:46:18Z","timestamp":1777448778000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327111400105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,28]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1177\/0960327111400105"],"URL":"https:\/\/doi.org\/10.1177\/0960327111400105","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,28]]}}}