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A total of 28 female rats were randomly assigned to 4 groups: (a) control ( n\u00a0=\u00a06 rats), (b) DOX group ( n\u00a0=\u00a07 rats), (c) DOX\u00a0+\u00a0ivabradine\u2013treated group ( n\u00a0=\u00a08 rats), and (d) ivabradine group ( n\u00a0=\u00a07 rats). When the means of the four groups were compared, there was only a significant difference in the level of HR ( p\u00a0&lt;\u00a00.05). DOX treatment caused more HR elevation when compared to the control group, whereas ivabradine application after DOX treatment significantly reduced HR levels. Cardiomyocytes were revealed as normal histology in the light of both hematoxylin and eosin staining and immunostaining methods (caspase-3 and bcl-2) in all groups. The present study reported the therapeutic effects of ivabradine against DOX-induced cardiotoxicity accompanied by the hemodynamic and biochemical parameters.<\/jats:p>","DOI":"10.1177\/0960327112438288","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:18:39Z","timestamp":1329869919000},"page":"945-954","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat"],"prefix":"10.1177","volume":"31","author":[{"given":"MC","family":"Colak","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Inonu University, Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Parlakpinar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Inonu University, Malatya, 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