{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:01:20Z","timestamp":1777669280840,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>\n                    It has been demonstrated that this sulfasalazine (SF) inhibits the nuclear factor \u03baB (NF\u03baB) pathway, which regulates important genes during inflammation and immune answer. The aim of this work was to evaluate the effects of SF on carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    )-induced liver fibrosis. We formed the following experimental groups of rats: controls, damage induced by chronic CCl\n                    <jats:sub>4<\/jats:sub>\n                    (0.4\u00a0g\/kg, intraperitoneally, three times a week for 8 weeks) administration and CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u00a0+\u00a0SF (100\u00a0mg\/kg\/day, postoperatively for 8 weeks) administration. We determined the activities of alanine aminotransferase (ALT), \u03b3-glutamyl transpeptidase (\u03b3-GTP), cyclooxygenase (COX)-1 and COX-2, lipid peroxidation, glutathione levels, collagen content, expression of transforming growth factor-\u03b2 (TGF-\u03b2) and nuclear translocation of NF\u03baB. SF was capable to inhibit the ALT and \u03b3-GTP elevated levels induced with the CCl\n                    <jats:sub>4<\/jats:sub>\n                    administration. SF had antioxidant properties, prevented the lipid peroxidation and the imbalance of reduced and oxidized glutathione produced by CCl\n                    <jats:sub>4<\/jats:sub>\n                    . Importantly, SF blocked the accumulation of collagen in the liver, the expression of TGF-\u03b2, the nuclear translocation of NF\u03baB and the activity of COX-2, all induced with the administration of CCl\n                    <jats:sub>4<\/jats:sub>\n                    in the rat. These results show that SF has strong antifibrotic properties because of its antioxidant properties and its ability to prevent nuclear translocation of NF\u03baB and consequently the expression of TGF-\u03b2 and the activity of COX-2.\n                  <\/jats:p>","DOI":"10.1177\/0960327112438928","type":"journal-article","created":{"date-parts":[[2012,3,3]],"date-time":"2012-03-03T15:33:09Z","timestamp":1330788789000},"page":"913-920","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Sulfasalazine prevents the increase in TGF-\u03b2, COX-2, nuclear NF\u03baB translocation and fibrosis in CCl\n                    <sub>4<\/sub>\n                    -induced liver cirrhosis in the rat"],"prefix":"10.1177","volume":"31","author":[{"given":"E","family":"Ch\u00e1vez","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Cinvestav-IPN, Apdo, M\u00e9xico, DF M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Castro-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Cinvestav-IPN, Apdo, M\u00e9xico, DF M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, Cinvestav-IPN, Apdo, M\u00e9xico, DF M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, Cinvestav-IPN, Apdo, M\u00e9xico, DF M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MG","family":"Moreno","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Cinvestav-IPN, Apdo, M\u00e9xico, DF M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Muriel","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Cinvestav-IPN, Apdo, M\u00e9xico, DF M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"key":"bibr1-0960327112438928","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199855040-00004"},{"key":"bibr2-0960327112438928","first-page":"1167","volume":"101","author":"Wahl C","year":"1997","journal-title":"J Clin 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