{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:17:27Z","timestamp":1791029847889,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T00:00:00Z","timestamp":1343260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>\n                    This study deals with the health effects within a child population, neighbouring a landfill. After detecting metals in soil and air samples collected in the surroundings of the landfill and in a control site, we have studied: (i) levels of lead (Pb) and exposure biomarkers in blood and urine, (ii) oxidative stress biomarkers and (iii) renal injury by applying a set of early effect biomarkers. Levels of Pb were higher in the exposed site (i.e. 1129 mg\/kg and 640 ng\/m\n                    <jats:sup>3<\/jats:sup>\n                    in soil and air samples, respectively) versus those in the control site (i.e. 14.3 mg\/kg and 9.3 ng\/m\n                    <jats:sup>3<\/jats:sup>\n                    in soil and air samples, respectively). Pb impregnation and levels of delta-aminolevulinic acid in urine were influenced by the living site that shows the prevailingly alarming situation in the Mbeubeuss landfill. Malondialdehyde changes indicated Pb-induced excessive production of reactive oxygen species. Lactate dehydrogenase activities and proteinuria were found to be higher in the children living in the exposed site. These evidences may reveal the usefulness of these two effect biomarkers to monitor the kidney injury entailed by relatively low-environmental exposure to Pb. Overall, these results show that the Mbeubeuss landfill constitutes a real source of environmental and health risk, be it living or working on site, of the surrounding population, predominantly for children.\n                  <\/jats:p>","DOI":"10.1177\/0960327112446815","type":"journal-article","created":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T14:52:42Z","timestamp":1343400762000},"page":"1280-1291","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Low-level environmental exposure to lead and renal adverse effects: A cross-sectional study in the population of children bordering the Mbeubeuss landfill near Dakar, Senegal"],"prefix":"10.1177","volume":"31","author":[{"given":"M","family":"Cabral","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Maison de la Recherche en Environnement Industriel 2, Universit\u00e9 du Littoral C\u00f4te d\u2019Opale, Dunkerque, France"},{"name":"Laboratoire de Chimie Analytique et Toxicologie, Facult\u00e9 de M\u00e9decine de Pharmacie et d'Odontologie, Universit\u00e9 Cheikh Anta Diop, Dakar, S\u00e9n\u00e9gal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Dieme","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Maison de la Recherche en Environnement Industriel 2, Universit\u00e9 du Littoral C\u00f4te d\u2019Opale, Dunkerque, France"},{"name":"Laboratoire de Chimie Analytique et Toxicologie, Facult\u00e9 de M\u00e9decine de Pharmacie et d'Odontologie, Universit\u00e9 Cheikh Anta Diop, Dakar, S\u00e9n\u00e9gal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Verdin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Maison de la Recherche en Environnement Industriel 2, Universit\u00e9 du Littoral C\u00f4te d\u2019Opale, Dunkerque, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Gar\u00e7on","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Maison de la Recherche en Environnement Industriel 2, Universit\u00e9 du Littoral C\u00f4te d\u2019Opale, Dunkerque, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Fall","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Analytique et Toxicologie, Facult\u00e9 de M\u00e9decine de Pharmacie et d'Odontologie, Universit\u00e9 Cheikh Anta Diop, Dakar, S\u00e9n\u00e9gal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bouhsina","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Maison de la Recherche en Environnement Industriel 2, Universit\u00e9 du Littoral C\u00f4te d\u2019Opale, Dunkerque, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Dewaele","sequence":"additional","affiliation":[{"name":"Centre Commun de Mesures, Maison de la Recherche en Environnement Industriel de Dunkerque 1, Universit\u00e9 du Littoral C\u00f4te d\u2019Opale, Dunkerque, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Cazier","sequence":"additional","affiliation":[{"name":"Centre Commun de Mesures, Maison de la Recherche en Environnement Industriel de Dunkerque 1, Universit\u00e9 du Littoral C\u00f4te d\u2019Opale, Dunkerque, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tall-Dia","sequence":"additional","affiliation":[{"name":"Institut de Sant\u00e9 et D\u00e9veloppement, Universit\u00e9 Cheikh Anta Diop, Dakar, S\u00e9n\u00e9gal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Diouf","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Analytique et Toxicologie, Facult\u00e9 de M\u00e9decine de Pharmacie et d'Odontologie, Universit\u00e9 Cheikh Anta Diop, Dakar, S\u00e9n\u00e9gal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Shirali","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Maison de la Recherche en Environnement Industriel 2, Universit\u00e9 du Littoral C\u00f4te d\u2019Opale, Dunkerque, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,7,26]]},"reference":[{"key":"bibr1-0960327112446815","unstructured":"Beauchemin C, Bocquier P. 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