{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:30:58Z","timestamp":1779366658786,"version":"3.53.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T00:00:00Z","timestamp":1351555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>\n                    Prolonged infusion of dexmedetomidine, an \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    -adrenoreceptor agonist anesthetic used in the intensive care unit, produces a withdrawal syndrome of sympathetic over-activity, characterized by tachycardia, hypertension and agitation, but there is no recommended standard treatment for this syndrome. We describe two patients with a clinical diagnosis of acute dexmedetomidine withdrawal and its management with oral clonidine. We utilized the principle of managing acute drug withdrawal with longer acting medications. These two cases demonstrated the benefit of using oral, longer acting clonidine to manage acute withdrawal from shorter-acting, intravenous dexmedetomidine.\n                  <\/jats:p>","DOI":"10.1177\/0960327112454896","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T23:43:59Z","timestamp":1351640639000},"page":"107-110","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Two cases of acute dexmedetomidine withdrawal syndrome following prolonged infusion in the intensive care unit"],"prefix":"10.1177","volume":"32","author":[{"given":"AT","family":"Kukoyi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SA","family":"Coker","sequence":"additional","affiliation":[{"name":"Section of Clinical Pharmacology, Department of Medicine, Geisel School of Medicine at Dartmouth and Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LD","family":"Lewis","sequence":"additional","affiliation":[{"name":"Section of Clinical Pharmacology, Department of Medicine, Geisel School of Medicine at Dartmouth and Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DW","family":"Nierenberg","sequence":"additional","affiliation":[{"name":"Section of Clinical Pharmacology, Department of Medicine, Geisel School of Medicine at Dartmouth and Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,10,30]]},"reference":[{"key":"bibr1-0960327112454896","doi-asserted-by":"publisher","DOI":"10.1053\/bean.2000.0094"},{"key":"bibr2-0960327112454896","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90744-3"},{"key":"bibr3-0960327112454896","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1579-9"},{"key":"bibr4-0960327112454896","unstructured":"Precedex (dexmedetomidine hydrochloride) prescribing information, http:\/\/www.precedex.com\/wp-content\/uploads\/2010\/02\/Precedex_Full_PI.pdf (2010, accessed 18 November 2011)."},{"key":"bibr5-0960327112454896","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02008.x"},{"key":"bibr6-0960327112454896","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181a66131"},{"key":"bibr7-0960327112454896","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2007.02377.x"},{"key":"bibr8-0960327112454896","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181ae49af"},{"key":"bibr9-0960327112454896","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197606000-00009"},{"key":"bibr10-0960327112454896","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-15.1.38"},{"key":"bibr11-0960327112454896","unstructured":"Catapress (clonidine hydrochloride, USP) prescribing information, http:\/\/bidocs.boehringer-ingelheim.com\/BIWebAccess\/ViewServlet.ser?docBase=renetnt&folderPath=\/Prescribing+Information\/PIs\/Catapres+Tabs\/CatapresTabs.pdf (2010, accessed 13 February 2012)."}],"container-title":["Human &amp; Experimental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327112454896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0960327112454896","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0960327112454896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:53:04Z","timestamp":1777449184000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0960327112454896"}},"subtitle":["Report of cases and review of the literature"],"short-title":[],"issued":{"date-parts":[[2012,10,30]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1177\/0960327112454896"],"URL":"https:\/\/doi.org\/10.1177\/0960327112454896","relation":{},"ISSN":["0960-3271","1477-0903"],"issn-type":[{"value":"0960-3271","type":"print"},{"value":"1477-0903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,30]]}}}