{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:12:42Z","timestamp":1790885562796,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T00:00:00Z","timestamp":1375833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>\n                    An overdose of acetaminophen (APAP) produces centrilobular hepatocellular necrosis. We aimed to investigate the hepatoprotective effects of N-acetylcysteine (NAC) only and hyperbaric oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ) treatment (HBOT) combined with NAC, and their anti-inflammatory properties in liver tissue. In the current study, a total of 32 male Sprague Dawley rats were divided into 4 groups: sham, APAP, NAC, and NAC + HBOT. In the APAP, NAC, and NAC + HBOT groups, liver injury was induced by oral administration of 1 g\/kg APAP. The NAC group received 100 mg\/kg NAC per day. NAC + HBOT group received intraperitoneal injection of 100 mg\/kg\/day NAC and were given HBOT at 2.8 ATA pressure with 100% O\n                    <jats:sub>2<\/jats:sub>\n                    inhalation for 90 min every 12 h for 5 days. Rats in the sham group received distilled water only by gastric tube. All animals were killed on day 6 after APAP or distilled water administration. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, hepatic neopterin, tumor necrosis factor-\u03b1 (TNF-\u03b1), and interleukin 6 (IL-6) levels were measured. There was a significant increase in serum AST and ALT activities in the APAP group compared with the sham group (in both p = 0.001). NAC and NAC + HBOT groups had significant decreases in hepatic neopterin, TNF-\u03b1, and IL-6 levels compared with the APAP group. APAP administration caused extensive hepatic necrosis. NAC and NAC + HBO treatments significantly reduced APAP-induced liver injury. Our results showed that the liver damage in APAP toxicity was attenuated by NAC and NAC + HBO treatments. NAC + HBOT exhibit hepatoprotective activity against APAP-induced liver injury in rats.\n                  <\/jats:p>","DOI":"10.1177\/0960327113499167","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T02:35:40Z","timestamp":1375929340000},"page":"1107-1116","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Hyperbaric oxygen treatment and\n                    <i>N<\/i>\n                    -acetylcysteine ameliorate acetaminophen-induced liver injury in a rat model"],"prefix":"10.1177","volume":"32","author":[{"given":"MY","family":"Taslipinar","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Diskapi Yildirim Beyazit Training and Research Hospital, Diskapi, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Gulhane 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