{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:36:19Z","timestamp":1777667779535,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T00:00:00Z","timestamp":1399507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>\n                    Long-acting injectable formulations of antipsychotics have been an important treatment option to increase the compliance of the patient with schizophrenia by monitoring drug administration and identifying medication noncompliance and to improve the long-term management of schizophrenia. Risperidone, a serotoninergic 5-HT\n                    <jats:sub>2<\/jats:sub>\n                    and dopaminergic D\n                    <jats:sub>2<\/jats:sub>\n                    receptor antagonist, was developed to be a long-acting sustained-release formulation for the treatment of schizophrenia. In this study, 12-week subchronic toxicity study of risperidone-loaded microspheres (RMs) in rats by intramuscular injection with an 8-week recovery phase was carried out to investigate the potential subchronic toxicity of a novel long-acting sustained-release formulation. The results indicated that the dosage of 10\u201390 mg\/kg of RM for 2 weeks did not cause treatment-related mortality. The main drug-related findings were contributed to the dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    receptor and \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -adrenoceptor antagonism of risperidone such as elevation of serum and pituitary prolactin levels and ptosis and changes in reproductive system (uterus, ovary, vagina, mammary gland, testis, seminal vesicle, epididymis, and prostate). In addition, foreign body granuloma in muscle at injection sites caused by poly-lactide-co-glycolide was observed. At the end of the recovery phase, these changes mostly returned to normal. The results indicated that RM had a good safety profile in rats.\n                  <\/jats:p>","DOI":"10.1177\/0960327114532380","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T02:40:08Z","timestamp":1399603208000},"page":"205-223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["A 12-week subchronic intramuscular toxicity study of risperidone-loaded microspheres in rats"],"prefix":"10.1177","volume":"34","author":[{"given":"J","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Yantai University and State Key Laboratory of Long-acting and Targeting Drug Delivery Technologies, Yantai, Shandong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Yantai University and State Key Laboratory of Long-acting and Targeting Drug Delivery Technologies, Yantai, Shandong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Yantai University and State Key Laboratory of Long-acting and Targeting Drug Delivery Technologies, Yantai, Shandong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Du","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Yantai University and State Key Laboratory of Long-acting and Targeting Drug Delivery Technologies, Yantai, Shandong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Yantai University and State Key Laboratory of Long-acting and Targeting Drug Delivery Technologies, Yantai, Shandong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Yantai University and State Key Laboratory of Long-acting and Targeting Drug Delivery Technologies, Yantai, Shandong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Yantai University and State Key Laboratory of Long-acting and Targeting Drug Delivery Technologies, Yantai, Shandong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Cen","sequence":"additional","affiliation":[{"name":"WestChina-Frontier PharmaTech Co. 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