{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:40:24Z","timestamp":1793137224347,"version":"4.5.0"},"reference-count":59,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:00:00Z","timestamp":1430179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Ionizing radiation is a widely used therapy for solid tumors. However, high-dose ionizing radiation causes apoptosis, transforms normal cells into tumor cells, and impairs immune functions, leading to the defects in the removal of damaged or tumor cells. In contrast, low-dose radiation has been reported to exert various beneficial effects in cells. This experimental study investigated the effect of \u03b3 rays at low dose on the development of colorectal tumor in a 1,2-dimethylhydrazine (DMH)-induced colon cancer. Colorectal tumor model was induced in Wistar rats by subcutaneous injection of DMH (20 mg\/kg) once a week for 15 weeks. Starting from zero day of DMH injection, a single low dose of whole-body \u03b3 irradiation of 0.5 Gy\/week was applied to the rats. A significant reduction in lipid peroxidation, nitric oxide, and elevation in the glutathione content and antioxidant enzyme activity (superoxide dismutase and catalase) were observed after \u03b3 irradiation comparing with DMH group. Moreover, \u03b3 ray reduced the expressions of multidrug resistance 1 (MDR1), \u03b2-catenin, and cytokeratin 20 (CK20) those increased in DMH-treated rats. However, survivin did not change with \u03b3 ray treatment. A histopathological examination of the DMH-injected rats revealed ulcerative colitis, dysplasia, anaplasia, and hyperchromasia. An improvement in the histopathological picture was seen in the colon of rats exposed to \u03b3 rays. In conclusion, the present results showed that low-dose \u03b3 ray significantly inhibited DMH-induced colon carcinogenesis in rats by modulating CK20, MDR1, and \u03b2-catenin expression but not survivin expression.<\/jats:p>","DOI":"10.1177\/0960327115584687","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T20:12:21Z","timestamp":1430338341000},"page":"282-292","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose \u03b3 rays by modulating multidrug resistance-1, cytokeratin 20, and \u03b2-catenin expression"],"prefix":"10.1177","volume":"35","author":[{"given":"HM","family":"Nabil","sequence":"first","affiliation":[{"name":"National Center for Radiation Research and Technology, Atomic Energy Authority (AEA), Cairo, 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