{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:39:16Z","timestamp":1777667956651,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Exp Toxicol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>\n                    This study investigated the molecular mechanism of the effect of sulfur dioxide (SO\n                    <jats:sub>2<\/jats:sub>\n                    ) on the expression of adenosine triphosphate (ATP)-sensitive potassium ion (K\n                    <jats:sup>+<\/jats:sup>\n                    ; K\n                    <jats:sub>ATP<\/jats:sub>\n                    ) channel, big-conductance calcium ion (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    )-activated K\n                    <jats:sup>+<\/jats:sup>\n                    (BK\n                    <jats:sub>Ca<\/jats:sub>\n                    ) channel, and L-type (L-Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) channel subunits in rat aortas with quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot. The results showed that the messenger RNA and protein levels of the K\n                    <jats:sub>ATP<\/jats:sub>\n                    channel subunits Kir6.1, Kir6.2, and sulfonylurea receptor 2B (SUR2B) of rat aortas were significantly increased by SO\n                    <jats:sub>2<\/jats:sub>\n                    at 14 mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    , whereas the levels of SUR2A were not changed. SO\n                    <jats:sub>2<\/jats:sub>\n                    at all the treated concentrations markedly raised the expression of the BK\n                    <jats:sub>Ca<\/jats:sub>\n                    channel subunits \u03b1 and \u03b21. SO\n                    <jats:sub>2<\/jats:sub>\n                    at 14 mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    significantly decreased the expression of the L-Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2 and Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.3. The histological examination of rat aorta tissues showed moderate injury of tunica media in the presence of SO\n                    <jats:sub>2<\/jats:sub>\n                    at 14 mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    . These suggest that SO\n                    <jats:sub>2<\/jats:sub>\n                    can activate the K\n                    <jats:sub>ATP<\/jats:sub>\n                    and BK\n                    <jats:sub>Ca<\/jats:sub>\n                    channels by upregulating the expression of Kir6.1, Kir6.2, SUR2B, BK\n                    <jats:sub>Ca<\/jats:sub>\n                    \u03b1, and BK\n                    <jats:sub>Ca<\/jats:sub>\n                    \u03b21, while inhibit the L-Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels by downregulating the expression of Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2 and Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.3 in rat aortas. The molecular mechanism of SO\n                    <jats:sub>2<\/jats:sub>\n                    -induced vasorelaxant effect might be linked to the changes in expression of these channel subunits, which plays an important role in the pathogenesis of SO\n                    <jats:sub>2<\/jats:sub>\n                    -associated cardiovascular diseases.\n                  <\/jats:p>","DOI":"10.1177\/0960327115591375","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T21:04:54Z","timestamp":1435266294000},"page":"418-427","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The molecular mechanism of the effect of sulfur dioxide inhalation on the potassium and calcium ion channels in rat aortas"],"prefix":"10.1177","volume":"35","author":[{"given":"Q","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Environmental Medicine and Toxicology, Institute of Environmental Science, Shanxi University, Taiyuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine and Toxicology, Institute of Environmental Science, Shanxi University, Taiyuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine and Toxicology, Institute of Environmental Science, Shanxi University, Taiyuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine and Toxicology, Institute of Environmental Science, Shanxi University, Taiyuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Meng","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine and Toxicology, Institute of Environmental Science, Shanxi University, Taiyuan, 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